Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study

Noel Conlisk; Rachael Forsythe; Lyam Hollis; Barry J Doyle; Olivia McBride; Jenny Robson; Chengjia Wang; Calum D Gray; Scott I K Semple; Tom MacGillivray; Edwin J R van Beek; David E Newby; Peter R Hoskins

doi:10.1007/s12265-017-9766-9

Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study

Noel Conlisk, Rachael Forsythe, Lyam Hollis, Barry J Doyle, Olivia McBride, Jenny Robson, Chengjia Wang, Calum D Gray, Scott I K Semple, Tom MacGillivray, Edwin J R van Beek, David E Newby, Peter R Hoskins

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Abstract / Description of output

Inflammation detected through the uptake of ultrasmall superparamagnetic particles of iron oxide (USPIO) on magnetic resonance imaging (MRI) and finite element (FE) modelling of tissue stress both hold potential in the assessment of abdominal aortic aneurysm (AAA) rupture risk. This study aimed to examine the spatial relationship between these two biomarkers. Patients (n = 50) > 40 years with AAA maximum diameters > = 40 mm underwent USPIO-enhanced MRI and computed tomography angiogram (CTA). USPIO uptake was compared with wall stress predictions from CTA-based patient-specific FE models of each aneurysm. Elevated stress was commonly observed in areas vulnerable to rupture (e.g. posterior wall and shoulder). Only 16% of aneurysms exhibited co-localisation of elevated stress and mural USPIO enhancement. Globally, no correlation was observed between stress and other measures of USPIO uptake (i.e. mean or peak). It is suggested that cellular inflammation and stress may represent different but complimentary aspects of AAA disease progression.

Original language	English
Journal	Journal of cardiovascular translational research
Early online date	14 Aug 2017
DOIs	https://doi.org/10.1007/s12265-017-9766-9
Publication status	E-pub ahead of print - 14 Aug 2017

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10.1007/s12265-017-9766-9

Hoskins P Exploring the Biological...
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Conlisk, N., Forsythe, R., Hollis, L., Doyle, B. J., McBride, O., Robson, J., Wang, C., Gray, C. D., Semple, S. I. K., MacGillivray, T., van Beek, E. J. R., Newby, D. E., & Hoskins, P. R. (2017). Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study. Journal of cardiovascular translational research. Advance online publication. https://doi.org/10.1007/s12265-017-9766-9

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abstract = "Inflammation detected through the uptake of ultrasmall superparamagnetic particles of iron oxide (USPIO) on magnetic resonance imaging (MRI) and finite element (FE) modelling of tissue stress both hold potential in the assessment of abdominal aortic aneurysm (AAA) rupture risk. This study aimed to examine the spatial relationship between these two biomarkers. Patients (n = 50) > 40 years with AAA maximum diameters > = 40 mm underwent USPIO-enhanced MRI and computed tomography angiogram (CTA). USPIO uptake was compared with wall stress predictions from CTA-based patient-specific FE models of each aneurysm. Elevated stress was commonly observed in areas vulnerable to rupture (e.g. posterior wall and shoulder). Only 16% of aneurysms exhibited co-localisation of elevated stress and mural USPIO enhancement. Globally, no correlation was observed between stress and other measures of USPIO uptake (i.e. mean or peak). It is suggested that cellular inflammation and stress may represent different but complimentary aspects of AAA disease progression.",

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Conlisk, N, Forsythe, R, Hollis, L, Doyle, BJ, McBride, O, Robson, J, Wang, C, Gray, CD , Semple, SIK , MacGillivray, T , van Beek, EJR , Newby, DE & Hoskins, PR 2017, 'Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study', Journal of cardiovascular translational research. https://doi.org/10.1007/s12265-017-9766-9

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T1 - Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress

T2 - A Combined Clinical and Finite Element Study

AU - Conlisk, Noel

AU - Forsythe, Rachael

AU - Hollis, Lyam

AU - Doyle, Barry J

AU - McBride, Olivia

AU - Robson, Jenny

AU - Wang, Chengjia

AU - Gray, Calum D

AU - Semple, Scott I K

AU - MacGillivray, Tom

AU - van Beek, Edwin J R

AU - Newby, David E

AU - Hoskins, Peter R

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AB - Inflammation detected through the uptake of ultrasmall superparamagnetic particles of iron oxide (USPIO) on magnetic resonance imaging (MRI) and finite element (FE) modelling of tissue stress both hold potential in the assessment of abdominal aortic aneurysm (AAA) rupture risk. This study aimed to examine the spatial relationship between these two biomarkers. Patients (n = 50) > 40 years with AAA maximum diameters > = 40 mm underwent USPIO-enhanced MRI and computed tomography angiogram (CTA). USPIO uptake was compared with wall stress predictions from CTA-based patient-specific FE models of each aneurysm. Elevated stress was commonly observed in areas vulnerable to rupture (e.g. posterior wall and shoulder). Only 16% of aneurysms exhibited co-localisation of elevated stress and mural USPIO enhancement. Globally, no correlation was observed between stress and other measures of USPIO uptake (i.e. mean or peak). It is suggested that cellular inflammation and stress may represent different but complimentary aspects of AAA disease progression.

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DO - 10.1007/s12265-017-9766-9

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ER -

Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study

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