Exploring the zoonotic potential of animal prion diseases: In vivo and in vitro approaches

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Following the discovery of a causal link between bovine spongiform encephalopathy (BSE) in cattle and variant Creutzfeldt-Jakob disease (vCJD) in humans, several experimental approaches have been used to try to assess the potential risk of transmission of other animal transmissible spongiform encephalopathies (TSEs) to humans. Experimental challenge of non-human primates, humanised transgenic mice and cell-free conversion systems have all been used as models to explore the susceptibility of humans to animal TSEs. In this review we compare and contrast in vivo and in vitro evidence of the zoonotic risk to humans from sheep, cattle and deer prions, focusing primarily on chronic wasting disease and our own recent studies using protein misfolding cyclic amplification.
Original languageEnglish
JournalPrion
Volume8
Issue number1
DOIs
Publication statusPublished - 18 Feb 2014

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