Exposure to nitrogen dioxide is not associated with vascular dysfunction in man

Jeremy P. Langrish, Magnus Lundback, Stefan Barath, Stefan Soderberg, Nicholas L. Mills, David E. Newby, Thomas Sandstrom, Anders Blomberg

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To investigate the effect of nitrogen dioxide exposure on vascular vasomotor and six fibrinolytic functions.

Methods: Ten healthy male volunteers were exposed to nitrogen dioxide at 4 ppm or filtered air for 1 h during intermittent exercise in a randomized double-blind crossover study. Bilateral forearm blood flow and fibrinolytic markers were measured before and during unilateral intrabrachial infusion of bradykinin (100-1000 pmol/min), acetylcholine (5-20 mu g/min), sodium nitroprusside (2-8 mu g/min), and verapamil (10-100 mu g/min) 4 h after the exposure. Lung function was determined before and after the exposure, and exhaled nitric oxide at baseline and 1 and 4 h after the exposure.

Results: There were no differences in resting forearm blood flow after either exposure. There was a dose-dependent increase in forearm blood flow with all vasodilators but this was similar after either exposure for all vasodilators (p > .05 for all). Bradykinin caused a dose-dependent increase in plasma tissue-plasminogen activator, but again there was no difference between the exposures. There were no changes in lung function or exhaled nitric oxide following either exposure.

Conclusion: Inhalation of nitrogen dioxide does not impair vascular vasomotor or fibrinolytic function. Nitrogen dioxide does not appear to be a major arbiter of the adverse cardiovascular effects of air pollution.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalInhalation Toxicology
Volume22
Issue number3
DOIs
Publication statusPublished - Feb 2010

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