Abstract
The receptor for bombesin and the related peptide, gastrin-releasing peptide (GRP) has been induced in frog oocytes by injection of polyA+ RNA from rat brain. The primed oocytes responded to peptides of the bombesin family (GRP, neuromedin C of bombesin) by showing dose-dependent oscillations in membrane currents as recorded by the voltage-clamp method. The induced membrane changes were suppressed when oocytes were pretreated with a bombesin-receptor antagonist.
| Original language | English |
|---|---|
| Pages (from-to) | 109-12 |
| Number of pages | 4 |
| Journal | FEBS Letters |
| Volume | 239 |
| Issue number | 1 |
| Publication status | Published - 24 Oct 1988 |
Keywords
- Animals
- Bombesin
- Brain
- Cell Membrane
- Female
- Gastrin-Releasing Peptide
- Membrane Potentials
- Microinjections
- Oocytes
- Peptides
- Poly A
- Protein Biosynthesis
- RNA
- RNA, Messenger
- Rats
- Receptors, Bombesin
- Receptors, Neurotransmitter
- Xenopus laevis