Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds

K Patel, R Nittenberg, D D'Souza, C Irving, D Burt, D G Wilkinson, C Tickle

Research output: Contribution to journalArticlepeer-review

Abstract

The Eph-related receptor tyrosine kinase gene, Cek-8, is expressed in mesenchyme at the tip of chick limb buds, with high levels of transcripts posteriorly and apically but fading out anteriorly. Expression of Cek-8 in distal mesenchyme is regulated by apical ridge- and FGF-polarising signals and retinoic acid, and is uniform across the anteroposterior axis in talpid3 mutants. These data indicate that Cek-8 expression responds to regulatory signals during limb patterning and suggest that this receptor tyrosine kinase may have a role in coordinating responses to signals in the progress zone of early buds. Later on in limb development, Cek-8 expression is associated with cell condensations that form tendons and their attachments to cartilage rudiments and then in developing feather buds.
Original languageEnglish
Pages (from-to)1147-55
Number of pages9
JournalDevelopment
Volume122
Issue number4
Publication statusPublished - 1996

Keywords

  • Patterning
  • Limb
  • tendon
  • feather
  • retinoic acid
  • Sonic hedgehog
  • EPH
  • receptor tyrosine kinase
  • Mouse
  • chick

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