Expression of BMP-4 mRNA during distraction osteogenesis in rabbits

G Li, S Berven, H Simpson, J T Triffitt

Research output: Contribution to journalArticlepeer-review


We characterized the presence and localization of bone morphogenetic protein 4 (BMP-4) mRNA in the regenerating tissues produced by distraction osteogenesis following tibial osteotomy in the rabbit. The findings are consistent with previous reports on the localization of BMP-4 mRNA expression during fracture repair. The BMP-4 gene is expressed by less differentiated osteoprogenitor cells (fibroblastic mesenchymal cells and preosteoblasts), and not by fully differentiated osteoblasts. BMP-4 gene expression is localized in callus-forming tissue (muscle, periosteum) during callus formation. Our observations suggest that the BMP-4 gene product is one of the local contributing factors in regulating bone and cartilage formation in distraction osteogenesis.

Original languageEnglish
Pages (from-to)420-5
Number of pages6
JournalActa Orthopaedica Scandinavica
Issue number4
Publication statusPublished - Aug 1998


  • Animals
  • Blotting, Northern
  • Bone Morphogenetic Protein 4
  • Bone Morphogenetic Proteins
  • Bone Regeneration
  • Disease Models, Animal
  • Gene Expression
  • Humans
  • In Situ Hybridization
  • Osteoblasts
  • Osteogenesis
  • Osteogenesis, Distraction
  • RNA, Messenger
  • Rabbits
  • Tibia


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