Abstract
We characterized the presence and localization of bone morphogenetic protein 4 (BMP-4) mRNA in the regenerating tissues produced by distraction osteogenesis following tibial osteotomy in the rabbit. The findings are consistent with previous reports on the localization of BMP-4 mRNA expression during fracture repair. The BMP-4 gene is expressed by less differentiated osteoprogenitor cells (fibroblastic mesenchymal cells and preosteoblasts), and not by fully differentiated osteoblasts. BMP-4 gene expression is localized in callus-forming tissue (muscle, periosteum) during callus formation. Our observations suggest that the BMP-4 gene product is one of the local contributing factors in regulating bone and cartilage formation in distraction osteogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 420-5 |
| Number of pages | 6 |
| Journal | Acta Orthopaedica Scandinavica |
| Volume | 69 |
| Issue number | 4 |
| Publication status | Published - Aug 1998 |
Keywords
- Animals
- Blotting, Northern
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins
- Bone Regeneration
- Disease Models, Animal
- Gene Expression
- Humans
- In Situ Hybridization
- Osteoblasts
- Osteogenesis
- Osteogenesis, Distraction
- RNA, Messenger
- Rabbits
- Tibia