Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoids

Colin Nixon, George Chambers, Victoria Ellsmore, M Saveria Campo, Paul Burr, David J Argyle, Stuart W J Reid, Lubna Nasir

Research output: Contribution to journalArticlepeer-review

Abstract

Equine sarcoids are benign fibroblastic skin tumours affecting equids worldwide. Whilst the pathogenesis is not entirely understood, infection with Bovine Papillomavirus (BPV) types 1 and 2 has been implicated as a major factor in the disease process, however the mechanism by which BPV infection contributes to sarcoid pathology is not clear. In this study, we show that the majority of sarcoids express the BPV-1 major transforming gene E6. Further, we demonstrate that sarcoid lesions are not associated with high levels of cellular proliferation as assessed by Ki67 expression or with expression of cell cycle regulators CDK-2, cyclin A and p27kip1. Our analysis of p53 shows that a subset of sarcoids are associated with abnormal cytoplasmic and nuclear expression of p53 and that the transactivation function of p53 is compromised in cells with cytoplasmic p53.
Original languageEnglish
Pages (from-to)237-45
Number of pages9
JournalCancer letters
Volume221
Issue number2
DOIs
Publication statusPublished - 2005

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