Abstract / Description of output
Activation of the hypoxia-inducible transcription factors HIF-1 and HIF-2 and a HIF-independent defect in developmental apoptosis have been implicated in the pathogenesis of pheochromocytoma (PCC) associated with VHL, SDHB, and SDHD mutations.
Original language | English |
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Pages (from-to) | 4593-8 |
Number of pages | 6 |
Journal | The Journal of Clinical Endocrinology & Metabolism (JCEM) |
Volume | 91 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2006 |
Keywords / Materials (for Non-textual outputs)
- Adrenal Gland Neoplasms
- Adrenal Medulla
- Basic Helix-Loop-Helix Transcription Factors
- Gene Expression Regulation, Neoplastic
- Germ-Line Mutation
- Head and Neck Neoplasms
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit
- Immunohistochemistry
- Paraganglioma
- Pheochromocytoma
- Succinate Dehydrogenase
- Transcription Factors
- Von Hippel-Lindau Tumor Suppressor Protein