TY - JOUR
T1 - Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha
AU - Collins, Frances
AU - MacPherson, Sheila
AU - Brown, Pamela
AU - Bombail, Vincent
AU - Williams, Alistair R W
AU - Anderson, Richard A
AU - Jabbour, Henry N
AU - Saunders, Philippa T K
PY - 2009/9/16
Y1 - 2009/9/16
N2 - Endometrial cancer is the most common gynaecological malignancy; risk factors include exposure to oestrogens and high body mass index. Expression of enzymes involved in biosynthesis of oestrogens and prostaglandins (PG) is often higher in endometrial cancers when compared with levels detected in normal endometrium. Oestrogens bind one of two receptors (ERalpha and ERbeta) encoded by separate genes. The full-length receptors function as ligand-activated transcription factors; splice variant isoforms of ERbeta lacking a ligand-binding domain have also been described. PGs act in an autocrine or paracrine manner by binding to specific G-protein coupled receptors.
AB - Endometrial cancer is the most common gynaecological malignancy; risk factors include exposure to oestrogens and high body mass index. Expression of enzymes involved in biosynthesis of oestrogens and prostaglandins (PG) is often higher in endometrial cancers when compared with levels detected in normal endometrium. Oestrogens bind one of two receptors (ERalpha and ERbeta) encoded by separate genes. The full-length receptors function as ligand-activated transcription factors; splice variant isoforms of ERbeta lacking a ligand-binding domain have also been described. PGs act in an autocrine or paracrine manner by binding to specific G-protein coupled receptors.
UR - http://www.scopus.com/inward/record.url?scp=70449434786&partnerID=8YFLogxK
U2 - 10.1186/1471-2407-9-330
DO - 10.1186/1471-2407-9-330
M3 - Article
C2 - 19758455
SN - 1471-2407
VL - 9
SP - 330
JO - BMC Cancer
JF - BMC Cancer
ER -