Expression of plasminogen activators and plasminogen activator inhibitors in squamous cell carcinoma of the lung is subject to marked regional variation

A. J. Simpson, W. A H Wallace, M. R. Jackson, G. K. Crompton, N. A. Booth

Research output: Contribution to journalArticlepeer-review

Abstract

The fibrinolytic enzyme system is thought to play an integral part in the invasion of extracellular matrix by malignant cells. We systematically examined the immunohistochemical distribution of plasminogen activators (t-PA, u-PA and u-PA receptor) and their inhibitors (PAI-1 and PAI-2) in topographically distinct regions within resected squamous cell lung carcinomas. Within tumours there were marked regional differences in the expression of plasminogen activators and plasminogen activator inhibitors by tumour cells, implying variations in fibrinolytic phenotype. In all tumours studied, the presence of tumour macrophages was associated with expression of PAI-1. The striking intra-tumoural variation observed has implications for the interpretation of clinical samples taken to study fibrinolytic phenotype, and supports the concept that fibrinolytic phenotype is critically dependent upon prevailing conditions in the tumour microenvironment.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalMedical Biochemistry
Volume1
Issue number4
Publication statusPublished - 1 Jan 2001

Keywords

  • Plasminogen activator inhibitors
  • Plasminogen activators
  • Squamous cell lung cancer

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