Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis

T J Nuttall, P A Knight, S M McAleese, J R Lamb, P B Hill

Research output: Contribution to journalArticlepeer-review

Abstract

Atopic dermatitis is a common inflammatory skin disease of humans and dogs. Human atopic dermatitis is associated with Th2-type responses, although Th1 cytokines can be identified in chronic lesions. In contrast, tolerance to environmental allergens in healthy individuals is mediated by regulatory T cells.
Original languageEnglish
Pages (from-to)789-95
Number of pages7
JournalClinical and Experimental Allergy
Volume32
Issue number5
Publication statusPublished - May 2002

Keywords

  • Animals
  • Cytokines
  • Dermatitis, Atopic
  • Dermatitis, Contact
  • Dog Diseases
  • Dogs
  • Humans
  • Immunosuppressive Agents
  • Interleukin-10
  • RNA, Messenger
  • Th1 Cells
  • Th2 Cells
  • Transcription, Genetic
  • Transforming Growth Factor beta

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