Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters

Michael D Oberst; Michael D Johnson; Robert B Dickson; Chen-Yong Lin; Baljit Singh; Moira Stewart; Alistair Williams; Awatif al-Nafussi; John F Smyth; Hani Gabra; Grant C Sellar

Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters

Michael D Oberst, Michael D Johnson, Robert B Dickson, Chen-Yong Lin, Baljit Singh, Moira Stewart, Alistair Williams, Awatif al-Nafussi, John F Smyth, Hani Gabra, Grant C Sellar

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Matriptase is a type II transmembrane serine protease expressed by cells of surface epithelial origin, including epithelial ovarian tumor cells. Matriptase cleaves and activates proteins implicated in the progression of ovarian cancer and represents a potential prognostic and therapeutic target. The aim of this study was to examine the expression of matriptase, and its inhibitor, hepatocyte growth factor activator inhibitor-1 (HAI-1), in epithelial ovarian cancer and to assign clinicopathological correlations.

Original language	English
Pages (from-to)	1101-7
Number of pages	7
Journal	Clinical Cancer Research
Volume	8
Issue number	4
Publication status	Published - Apr 2002

Keywords

Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
In Situ Hybridization
Membrane Glycoproteins
Neoplasm Staging
Ovarian Neoplasms
Proportional Hazards Models
Proteinase Inhibitory Proteins, Secretory
RNA, Messenger
Serine Endopeptidases
Survival Analysis
Trypsin
Tumor Cells, Cultured

Cite this

Oberst, M. D., Johnson, M. D., Dickson, R. B., Lin, C-Y., Singh, B., Stewart, M., Williams, A., al-Nafussi, A., Smyth, J. F., Gabra, H., & Sellar, G. C. (2002). Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters. Clinical Cancer Research, 8(4), 1101-7.

@article{b1818bdaf06847e7b58215a07a4e88b2,

title = "Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters",

abstract = "Matriptase is a type II transmembrane serine protease expressed by cells of surface epithelial origin, including epithelial ovarian tumor cells. Matriptase cleaves and activates proteins implicated in the progression of ovarian cancer and represents a potential prognostic and therapeutic target. The aim of this study was to examine the expression of matriptase, and its inhibitor, hepatocyte growth factor activator inhibitor-1 (HAI-1), in epithelial ovarian cancer and to assign clinicopathological correlations.",

keywords = "Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, In Situ Hybridization, Membrane Glycoproteins, Neoplasm Staging, Ovarian Neoplasms, Proportional Hazards Models, Proteinase Inhibitory Proteins, Secretory, RNA, Messenger, Serine Endopeptidases, Survival Analysis, Trypsin, Tumor Cells, Cultured",

author = "Oberst, {Michael D} and Johnson, {Michael D} and Dickson, {Robert B} and Chen-Yong Lin and Baljit Singh and Moira Stewart and Alistair Williams and Awatif al-Nafussi and Smyth, {John F} and Hani Gabra and Sellar, {Grant C}",

year = "2002",

month = apr,

language = "English",

volume = "8",

pages = "1101--7",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

number = "4",

}

Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer : correlation with clinical outcome and tumor clinicopathological parameters. / Oberst, Michael D; Johnson, Michael D; Dickson, Robert B et al.

In: Clinical Cancer Research, Vol. 8, No. 4, 04.2002, p. 1101-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer

T2 - correlation with clinical outcome and tumor clinicopathological parameters

AU - Oberst, Michael D

AU - Johnson, Michael D

AU - Dickson, Robert B

AU - Lin, Chen-Yong

AU - Singh, Baljit

AU - Stewart, Moira

AU - Williams, Alistair

AU - al-Nafussi, Awatif

AU - Smyth, John F

AU - Gabra, Hani

AU - Sellar, Grant C

PY - 2002/4

Y1 - 2002/4

N2 - Matriptase is a type II transmembrane serine protease expressed by cells of surface epithelial origin, including epithelial ovarian tumor cells. Matriptase cleaves and activates proteins implicated in the progression of ovarian cancer and represents a potential prognostic and therapeutic target. The aim of this study was to examine the expression of matriptase, and its inhibitor, hepatocyte growth factor activator inhibitor-1 (HAI-1), in epithelial ovarian cancer and to assign clinicopathological correlations.

AB - Matriptase is a type II transmembrane serine protease expressed by cells of surface epithelial origin, including epithelial ovarian tumor cells. Matriptase cleaves and activates proteins implicated in the progression of ovarian cancer and represents a potential prognostic and therapeutic target. The aim of this study was to examine the expression of matriptase, and its inhibitor, hepatocyte growth factor activator inhibitor-1 (HAI-1), in epithelial ovarian cancer and to assign clinicopathological correlations.

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Membrane Glycoproteins

KW - Neoplasm Staging

KW - Ovarian Neoplasms

KW - Proportional Hazards Models

KW - Proteinase Inhibitory Proteins, Secretory

KW - RNA, Messenger

KW - Serine Endopeptidases

KW - Survival Analysis

KW - Trypsin

KW - Tumor Cells, Cultured

M3 - Article

C2 - 11948120

VL - 8

SP - 1101

EP - 1107

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 4

ER -

Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters

Abstract

Keywords

Fingerprint

Cite this