Expression of TopBP1 in canine mammary neoplasia in relation to histological type, Ki67, ERalpha and p53

Joanna S Morris, Colin Nixon, Oliver J A King, Iain M Morgan, Adrian W Philbey

Research output: Contribution to journalArticlepeer-review

Abstract

TopBP1 is aberrantly expressed in human and feline mammary carcinomas, but expression of this BRCA1-related protein has not been investigated in canine mammary carcinomas. In this study, 132 canine mammary tumours (46 benign, 86 carcinomas) were examined immunohistochemically for expression of TopBP1, oestrogen receptor alpha (ERalpha), Ki67 and p53. Positive staining for TopBP1 was evident in all canine mammary lesions, although five samples had
Original languageEnglish
Pages (from-to)422-9
Number of pages8
JournalVeterinary Journal
Volume179
Issue number3
DOIs
Publication statusPublished - 2009

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