Extended ncRNAs interfere with promoter nucleosome dynamics

Tomasz Turowski; David Tollervey

doi:10.1016/j.tig.2020.05.011

Extended ncRNAs interfere with promoter nucleosome dynamics

Tomasz Turowski, David Tollervey

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Eukaryotic genomes generate vast numbers of ncRNA that can inhibit mRNA synthesis through transcription interference, but the mechanisms were unclear. A recent paper [1]shows that transcription of anti-sense, ncRNAs induces “elongation marks“ on histones in promoter regions. These inhibit active nucleosome positioning required to maintain open transcription-initiation sites.

Original language	English
Journal	Trends in Genetics
DOIs	https://doi.org/10.1016/j.tig.2020.05.011
Publication status	Published - 13 Jun 2020

Keywords / Materials (for Non-textual outputs)

transcription
chromatin
antisense transcript
nuclear surveillance

Access to Document

10.1016/j.tig.2020.05.011

TollerveyEtal2020ExtendedncRNAsInterfereWithPromoterNucleosomeAccepted author manuscript, 1.78 MB

Wellcome Centre for Cell Biology
Tollervey, D.
UK-based charities
1/12/16 → 1/12/21
Project: Research

Cite this

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title = "Extended ncRNAs interfere with promoter nucleosome dynamics",

abstract = "Eukaryotic genomes generate vast numbers of ncRNA that can inhibit mRNA synthesis through transcription interference, but the mechanisms were unclear. A recent paper [1]shows that transcription of anti-sense, ncRNAs induces “elongation marks“ on histones in promoter regions. These inhibit active nucleosome positioning required to maintain open transcription-initiation sites.",

keywords = "transcription, chromatin, antisense transcript, nuclear surveillance",

author = "Tomasz Turowski and David Tollervey",

year = "2020",

month = jun,

day = "13",

doi = "10.1016/j.tig.2020.05.011",

language = "English",

journal = "Trends in Genetics",

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TY - JOUR

T1 - Extended ncRNAs interfere with promoter nucleosome dynamics

AU - Turowski, Tomasz

AU - Tollervey, David

PY - 2020/6/13

Y1 - 2020/6/13

N2 - Eukaryotic genomes generate vast numbers of ncRNA that can inhibit mRNA synthesis through transcription interference, but the mechanisms were unclear. A recent paper [1]shows that transcription of anti-sense, ncRNAs induces “elongation marks“ on histones in promoter regions. These inhibit active nucleosome positioning required to maintain open transcription-initiation sites.

AB - Eukaryotic genomes generate vast numbers of ncRNA that can inhibit mRNA synthesis through transcription interference, but the mechanisms were unclear. A recent paper [1]shows that transcription of anti-sense, ncRNAs induces “elongation marks“ on histones in promoter regions. These inhibit active nucleosome positioning required to maintain open transcription-initiation sites.

KW - transcription

KW - chromatin

KW - antisense transcript

KW - nuclear surveillance

U2 - 10.1016/j.tig.2020.05.011

DO - 10.1016/j.tig.2020.05.011

M3 - Article

SN - 0168-9525

JO - Trends in Genetics

JF - Trends in Genetics

ER -

Extended ncRNAs interfere with promoter nucleosome dynamics

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

Wellcome Centre for Cell Biology

Cite this