Extended ncRNAs interfere with promoter nucleosome dynamics

Research output: Contribution to journalArticlepeer-review

Abstract

Eukaryotic genomes generate vast numbers of ncRNA that can inhibit mRNA synthesis through transcription interference, but the mechanisms were unclear. A recent paper [1]shows that transcription of anti-sense, ncRNAs induces “elongation marks“ on histones in promoter regions. These inhibit active nucleosome positioning required to maintain open transcription-initiation sites.
Original languageEnglish
JournalTrends in Genetics
DOIs
Publication statusPublished - 13 Jun 2020

Keywords

  • transcription
  • chromatin
  • antisense transcript
  • nuclear surveillance

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