Extracolonic features of familial adenomatous polyposis in patients with sporadic colorectal cancer

M G Dunlop, S M Farrington, V J Bubb, C Cunningham, M Wright, L J Curtis, Z A Butt, E Wright, B W Fleck, D Redhead, Richard Mitchell, J B Rainey, I M Macintyre, D C Carter, A H Wyllie

Research output: Contribution to journalArticlepeer-review

Abstract

We have investigated the occurrence of attenuated extracolonic manifestations (AEMs) of familial adenomatous polyposis (FAP) in patients with non-polyposis colorectal cancer. In a prospective case-control study, we observed that significantly more colorectal cancer patients exhibited AEM than did age and sex-matched controls (19.5% vs 7.5%, P
Original languageEnglish
Pages (from-to)1789-95
Number of pages7
JournalBritish Journal of Cancer
Volume74
Issue number11
Publication statusPublished - Dec 1996

Keywords

  • Adenomatous Polyposis Coli
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Colorectal Neoplasms
  • DNA Mutational Analysis
  • DNA Replication
  • DNA, Neoplasm
  • Female
  • Genes, APC
  • Humans
  • Hypertrophy
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Phenotype
  • Pigment Epithelium of Eye
  • Prospective Studies

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