Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition

Dongxing Zhu; Xiaosa Li; Vicky E Macrae; Tommaso Simoncini; Xiaodong Fu

doi:10.1016/j.tem.2018.06.001

Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition

Dongxing Zhu, Xiaosa Li, Vicky E Macrae, Tommaso Simoncini, Xiaodong Fu

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimulating hormone (FSH) levels rise sharply during menopausal transition and are maintained at elevated levels for many years. FSH receptor has been detected in various extragonadal sites, including osteoclasts and endothelial cells. Recent advances suggest FSH may contribute to postmenopausal osteoporosis and cardiovascular disease. Here, we review the key actions through which FSH contributes to the risk of osteoporosis and cardiovascular disease in women as they transition through menopause. Advancing our understanding of the precise mechanisms through which FSH promotes osteoporosis and cardiovascular disease may provide new opportunities for improving health-span for postmenopausal women.

Original language	English
Pages (from-to)	571-580
Journal	Trends in Endocrinology & Metabolism
Volume	29
Issue number	8
Early online date	5 Jul 2018
DOIs	https://doi.org/10.1016/j.tem.2018.06.001
Publication status	E-pub ahead of print - 5 Jul 2018

Keywords / Materials (for Non-textual outputs)

Follicle-stimulating hormone
postmenopause;
osteoporosis
cardiovascular disease
extragonadal effects

Access to Document

10.1016/j.tem.2018.06.001

Extragonadal Effects of Follicle-Stimulating Hormone on OsteoporosisAccepted author manuscript, 3.72 MBLicence: CC BY-NC-ND

Control of development and reproductive traits
Burdon, T., Argyle, D., Ashworth, C., Beard, P., Brunton, P., Burt, D., Clinton, M., Dunn, I., Farquharson, C., Headon, D., Hocking, P., Hohenstein, P., Hume, D., Jackson, I., McColl, B., McGrew, M., McLachlan, G., Sang, H., Summers, K. & Whitelaw, B.
BBSRC
1/04/12 → 31/03/17
Project: Research

Cite this

@article{93f9b1f93c0d4d4fb18c63842d2d075d,

title = "Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition",

abstract = "The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimulating hormone (FSH) levels rise sharply during menopausal transition and are maintained at elevated levels for many years. FSH receptor has been detected in various extragonadal sites, including osteoclasts and endothelial cells. Recent advances suggest FSH may contribute to postmenopausal osteoporosis and cardiovascular disease. Here, we review the key actions through which FSH contributes to the risk of osteoporosis and cardiovascular disease in women as they transition through menopause. Advancing our understanding of the precise mechanisms through which FSH promotes osteoporosis and cardiovascular disease may provide new opportunities for improving health-span for postmenopausal women.",

keywords = "Follicle-stimulating hormone, postmenopause;, osteoporosis, cardiovascular disease, extragonadal effects",

author = "Dongxing Zhu and Xiaosa Li and Macrae, {Vicky E} and Tommaso Simoncini and Xiaodong Fu",

year = "2018",

month = jul,

day = "5",

doi = "10.1016/j.tem.2018.06.001",

language = "English",

volume = "29",

pages = "571--580",

journal = "Trends in Endocrinology & Metabolism",

issn = "1043-2760",

publisher = "Cell Press",

number = "8",

}

TY - JOUR

T1 - Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition

AU - Zhu, Dongxing

AU - Li, Xiaosa

AU - Macrae, Vicky E

AU - Simoncini, Tommaso

AU - Fu, Xiaodong

PY - 2018/7/5

Y1 - 2018/7/5

N2 - The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimulating hormone (FSH) levels rise sharply during menopausal transition and are maintained at elevated levels for many years. FSH receptor has been detected in various extragonadal sites, including osteoclasts and endothelial cells. Recent advances suggest FSH may contribute to postmenopausal osteoporosis and cardiovascular disease. Here, we review the key actions through which FSH contributes to the risk of osteoporosis and cardiovascular disease in women as they transition through menopause. Advancing our understanding of the precise mechanisms through which FSH promotes osteoporosis and cardiovascular disease may provide new opportunities for improving health-span for postmenopausal women.

AB - The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimulating hormone (FSH) levels rise sharply during menopausal transition and are maintained at elevated levels for many years. FSH receptor has been detected in various extragonadal sites, including osteoclasts and endothelial cells. Recent advances suggest FSH may contribute to postmenopausal osteoporosis and cardiovascular disease. Here, we review the key actions through which FSH contributes to the risk of osteoporosis and cardiovascular disease in women as they transition through menopause. Advancing our understanding of the precise mechanisms through which FSH promotes osteoporosis and cardiovascular disease may provide new opportunities for improving health-span for postmenopausal women.

KW - Follicle-stimulating hormone

KW - postmenopause;

KW - osteoporosis

KW - cardiovascular disease

KW - extragonadal effects

U2 - 10.1016/j.tem.2018.06.001

DO - 10.1016/j.tem.2018.06.001

M3 - Review article

C2 - 29983231

SN - 1043-2760

VL - 29

SP - 571

EP - 580

JO - Trends in Endocrinology & Metabolism

JF - Trends in Endocrinology & Metabolism

IS - 8

ER -

Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

Control of development and reproductive traits

Cite this