Extremes of baseline cognitive function determine the severity of delirium: a population study

Alex Tsui, Natalie Yeo, Samuel D Searle, Helen Bowden, Katrin Hoffmann, Joanne Hornby, Arley Goslett, Maryse Weston-Clarke, David Lanham, Patrick Hogan, Anna Seeley, Mark Rawle, Nish Chaturvedi, Elizabeth L Sampson, Kenneth Rockwood, Colm Cunningham, E Wesley Ely, Sarah J Richardson, Carol Brayne, Graciela Muniz TerreraZoë Tieges, Alasdair M J MacLullich, Daniel Davis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Though delirium is a significant clinical and public health problem, little is understood about how specific vulnerabilities underlie the severity of its presentation. Our objective was to quantify the relationship between baseline cognition and subsequent delirium severity. We prospectively investigated a population-representative sample of 1510 individuals aged ≥70 years, of whom 209 (13.6%) were hospitalised across 371 episodes (1,999 person-days assessment). Baseline cognitive function was assessed using the modified Telephone Interview for Cognitive Status, supplemented by verbal fluency measures. We estimated the relationship between baseline cognition and delirium severity (Memorial Delirium Assessment Scale, MDAS) and abnormal arousal (Observational Scale for Level of Arousal), adjusted by age, sex, frailty and illness severity. We conducted further analyses examining presentations to specific hospital settings and common precipitating aetiologies. The median time from baseline cognitive assessment to admission was 289 days (interquartile range 130 to 47 days). In admitted patients, delirium was present on at least one day in 45% of admission episodes. The average number of days with delirium (consecutively positive assessments) was 3.9 days. Elective admissions accounted for 88 bed-days (4.4%). In emergency (but not elective) admissions, we found a non-linear U-shaped relationship between baseline global cognition and delirium severity using restricted cubic splines. Participants with baseline cognition two standard deviations (SD) below average (z-score = -2) had a mean MDAS score of 14 points (95% CI 10 to 19). Similarly, those with baseline cognition z-score = +2 had a mean MDAS score of 7.9 points (95% CI 4.9 to 11). Individuals with average baseline cognition had the lowest MDAS scores. The association between baseline cognition and abnormal arousal followed a comparable pattern. C-reactive protein ≥20 mg/L and serum sodium <125 mM/L were associated with more severe delirium. Baseline cognition is a critical determinant of the severity of delirium and associated changes in arousal. Emergency admissions with lowest and highest baseline cognition who develop delirium should receive enhanced clinical attention.

Original languageEnglish
Early online date28 Feb 2023
Publication statusE-pub ahead of print - 28 Feb 2023


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