Factors affecting trypanosome maturation in tsetse flies.

Research output: Contribution to journalArticlepeer-review

Abstract

Trypanosoma brucei brucei infections which establish successfully in the tsetse fly midgut may subsequently mature into mammalian infective trypanosomes in the salivary glands. This maturation is not automatic and the control of these events is complex. Utilising direct in vivo feeding experiments, we report maturation of T. b. brucei infections in tsetse is regulated by antioxidants as well as environmental stimuli. Dissection of the maturation process provides opportunities to develop transmission blocking vaccines for trypanosomiasis. The present work suggests L-cysteine and/or nitric oxide are necessary for the differentiation of trypanosome midgut infections in tsetse.
Original languageEnglish
JournalPLoS ONE
DOIs
Publication statusPublished - 2007

Keywords

  • tsetse
  • cgmp
  • Nitric Oxide
  • Cysteine

Fingerprint

Dive into the research topics of 'Factors affecting trypanosome maturation in tsetse flies.'. Together they form a unique fingerprint.

Cite this