Factors affecting trypanosome maturation in tsetse flies.

Ewan MacLeod; Susan Welburn

doi:10.1371/journal.pone.0000239

Factors affecting trypanosome maturation in tsetse flies.

Research output: Contribution to journal › Article › peer-review

Abstract

Trypanosoma brucei brucei infections which establish successfully in the tsetse fly midgut may subsequently mature into mammalian infective trypanosomes in the salivary glands. This maturation is not automatic and the control of these events is complex. Utilising direct in vivo feeding experiments, we report maturation of T. b. brucei infections in tsetse is regulated by antioxidants as well as environmental stimuli. Dissection of the maturation process provides opportunities to develop transmission blocking vaccines for trypanosomiasis. The present work suggests L-cysteine and/or nitric oxide are necessary for the differentiation of trypanosome midgut infections in tsetse.

Original language	English
Journal	PLoS ONE
DOIs	https://doi.org/10.1371/journal.pone.0000239
Publication status	Published - 2007

Keywords / Materials (for Non-textual outputs)

tsetse
cgmp
Nitric Oxide
Cysteine

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10.1371/journal.pone.0000239

Factors affecting trypanosome maturation in tsetse flies.
Copyright: © 2007 MacLeod et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 142 KBLicence: Creative Commons: Attribution (CC-BY)

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000239

Cite this

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title = "Factors affecting trypanosome maturation in tsetse flies.",

abstract = "Trypanosoma brucei brucei infections which establish successfully in the tsetse fly midgut may subsequently mature into mammalian infective trypanosomes in the salivary glands. This maturation is not automatic and the control of these events is complex. Utilising direct in vivo feeding experiments, we report maturation of T. b. brucei infections in tsetse is regulated by antioxidants as well as environmental stimuli. Dissection of the maturation process provides opportunities to develop transmission blocking vaccines for trypanosomiasis. The present work suggests L-cysteine and/or nitric oxide are necessary for the differentiation of trypanosome midgut infections in tsetse.",

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AB - Trypanosoma brucei brucei infections which establish successfully in the tsetse fly midgut may subsequently mature into mammalian infective trypanosomes in the salivary glands. This maturation is not automatic and the control of these events is complex. Utilising direct in vivo feeding experiments, we report maturation of T. b. brucei infections in tsetse is regulated by antioxidants as well as environmental stimuli. Dissection of the maturation process provides opportunities to develop transmission blocking vaccines for trypanosomiasis. The present work suggests L-cysteine and/or nitric oxide are necessary for the differentiation of trypanosome midgut infections in tsetse.

KW - tsetse

KW - cgmp

KW - Nitric Oxide

KW - Cysteine

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M3 - Article

SN - 1932-6203

JO - PLoS ONE

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ER -

Factors affecting trypanosome maturation in tsetse flies.

Abstract

Keywords / Materials (for Non-textual outputs)

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