Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study

Sarah L Lambton; Adrian D Colloff; Richard P Smith; George L Caldow; Sandra F E Scholes; Kim Willoughby; Fiona Howie; Johanne Ellis-Iversen; Graham David; Alasdair J C Cook; Andrew Holliman

doi:10.1371/journal.pone.0034183

Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study

Sarah L Lambton, Adrian D Colloff, Richard P Smith, George L Caldow, Sandra F E Scholes, Kim Willoughby, Fiona Howie, Johanne Ellis-Iversen, Graham David, Alasdair J C Cook, Andrew Holliman

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure® BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p

Original language	English
Pages (from-to)	e34183
Journal	PLoS ONE
Volume	7
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0034183
Publication status	Published - 2012

Keywords

Animals
Animals, Newborn
Case-Control Studies
Cattle
Cattle Diseases
Diarrhea Viruses, Bovine Viral
Female
Great Britain
Logistic Models
Male
Pancytopenia
Pregnancy
Retrospective Studies
Risk Factors
Vaccination
Viral Vaccines

Access to Document

10.1371/journal.pone.0034183

Factors associated with bovine neonatal pancytopenia (BNP) in calves
Copyright: © 2012 Crown Copyright. This is an open-access article distributed under the terms of the free Open Government Licence, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Final published version, 93.3 KB

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0034183

Cite this

@article{4478059e029b4bff80aabb15547ba0b2,

title = "Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study",

abstract = "Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure{\textregistered} BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p",

keywords = "Animals, Animals, Newborn, Case-Control Studies, Cattle, Cattle Diseases, Diarrhea Viruses, Bovine Viral, Female, Great Britain, Logistic Models, Male, Pancytopenia, Pregnancy, Retrospective Studies, Risk Factors, Vaccination, Viral Vaccines",

author = "Lambton, {Sarah L} and Colloff, {Adrian D} and Smith, {Richard P} and Caldow, {George L} and Scholes, {Sandra F E} and Kim Willoughby and Fiona Howie and Johanne Ellis-Iversen and Graham David and Cook, {Alasdair J C} and Andrew Holliman",

year = "2012",

doi = "10.1371/journal.pone.0034183",

language = "English",

volume = "7",

pages = "e34183",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "5",

}

Factors associated with bovine neonatal pancytopenia (BNP) in calves : a case-control study. / Lambton, Sarah L; Colloff, Adrian D; Smith, Richard P; Caldow, George L; Scholes, Sandra F E; Willoughby, Kim; Howie, Fiona; Ellis-Iversen, Johanne; David, Graham; Cook, Alasdair J C; Holliman, Andrew.

In: PLoS ONE, Vol. 7, No. 5, 2012, p. e34183.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Factors associated with bovine neonatal pancytopenia (BNP) in calves

T2 - a case-control study

AU - Lambton, Sarah L

AU - Colloff, Adrian D

AU - Smith, Richard P

AU - Caldow, George L

AU - Scholes, Sandra F E

AU - Willoughby, Kim

AU - Howie, Fiona

AU - Ellis-Iversen, Johanne

AU - David, Graham

AU - Cook, Alasdair J C

AU - Holliman, Andrew

PY - 2012

Y1 - 2012

N2 - Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure® BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p

AB - Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure® BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p

KW - Animals

KW - Animals, Newborn

KW - Case-Control Studies

KW - Cattle

KW - Cattle Diseases

KW - Diarrhea Viruses, Bovine Viral

KW - Female

KW - Great Britain

KW - Logistic Models

KW - Male

KW - Pancytopenia

KW - Pregnancy

KW - Retrospective Studies

KW - Risk Factors

KW - Vaccination

KW - Viral Vaccines

U2 - 10.1371/journal.pone.0034183

DO - 10.1371/journal.pone.0034183

M3 - Article

C2 - 22606224

VL - 7

SP - e34183

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 5

ER -

Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study

Abstract

Keywords

Access to Document

Fingerprint

Cite this