Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study

Sarah L Lambton, Adrian D Colloff, Richard P Smith, George L Caldow, Sandra F E Scholes, Kim Willoughby, Fiona Howie, Johanne Ellis-Iversen, Graham David, Alasdair J C Cook, Andrew Holliman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure® BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p
Original languageEnglish
Pages (from-to)e34183
JournalPLoS ONE
Issue number5
Publication statusPublished - 2012

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Animals, Newborn
  • Case-Control Studies
  • Cattle
  • Cattle Diseases
  • Diarrhea Viruses, Bovine Viral
  • Female
  • Great Britain
  • Logistic Models
  • Male
  • Pancytopenia
  • Pregnancy
  • Retrospective Studies
  • Risk Factors
  • Vaccination
  • Viral Vaccines

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