FAK to the Rescue: Activated Stroma Promotes a "Safe Haven'' for BRAF-Mutant Melanoma Cells by Inducing FAK Signaling

Margaret C. Frame*, Alan Serrels

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

Abstract

Perhaps the most pressing need in cancer therapeutics is to understand drug resistance. In this issue of Cancer Cell, Hirata and colleagues show that melanoma-associated fibroblasts can drive resistance to the BRAF inhibitor PLX4720 by stimulating matrix production/remodeling, and, consequently, survival signaling in melanoma cells via beta 1-integrin, Src, and FAK.

Original languageEnglish
Pages (from-to)429-431
Number of pages3
JournalCancer Cell
Volume27
Issue number4
DOIs
Publication statusPublished - 13 Apr 2015

Keywords

  • FOCAL-ADHESION KINASE
  • CANCER

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