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Abstract / Description of output
False discovery rate (FDR) estimation is a cornerstone of proteomics that has recently been adapted to cross-linking/mass spectrometry. Here we demonstrate that heterobifunctional cross-linkers, while theoretically different from homobifunctional cross-linkers, need not be considered separately in practice. We develop and then evaluate the impact of applying a correct FDR formula for use of heterobifunctional cross-linkers and conclude that there are minimal practical advantages. Hence a single formula can be applied to data generated from the many different non-cleavable cross-linkers.
Original language | English |
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Article number | e0196672 |
Journal | PLoS ONE |
Volume | 13 |
Issue number | 5 |
DOIs | |
Publication status | Published - 10 May 2018 |
Keywords / Materials (for Non-textual outputs)
- Journal Article
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Dive into the research topics of 'False discovery rate estimation and heterobifunctional cross-linkers'. Together they form a unique fingerprint.Projects
- 2 Finished
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Protein structures in the context of time and space by mass spectrometry
1/06/14 → 31/05/21
Project: Research