Familial high risk and high-risk studies

Liana Romaniuk; Stella W.Y. Chan; Alix Macdonald; Jessika E. Sussmann; Andrew M. McIntosh; Heather C. Whalley; Stephen M. Lawrie

doi:10.1016/B978-0-12-813201-2.00006-5

Familial high risk and high-risk studies

Liana Romaniuk, Stella W.Y. Chan, Alix Macdonald, Jessika E. Sussmann, Andrew M. McIntosh, Heather C. Whalley, Stephen M. Lawrie

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract / Description of output

A prominent risk factor for psychosis is its high heritability. This offers us a means to identify potential biomarkers of risk and resilience by focusing on people who are at familial high risk, but are currently free of both illness and medication. The genetic underpinnings of this risk allow us to gain a more mechanistic understanding, which may better guide therapeutic development and prevention strategies. Here, we summarize two prospective longitudinal familial high-risk studies: the Edinburgh High Risk Study of schizophrenia and the Bipolar Family Study. This work highlights the complex interactions between molecular mechanisms and environmental circumstances in the generation and perpetuation of psychosis.

Original language	English
Title of host publication	Risk Factors for Psychosis
Subtitle of host publication	Paradigms, Mechanisms, and Prevention
Publisher	Elsevier
Chapter	6
Pages	101-117
Number of pages	17
ISBN (Electronic)	9780128132012
ISBN (Print)	9780128132029
DOIs	https://doi.org/10.1016/B978-0-12-813201-2.00006-5
Publication status	Published - 1 Jan 2020

Keywords / Materials (for Non-textual outputs)

Bipolar affective disorder
Cohort study
Familial high risk
Genetic risk
Longitudinal
MRI
Psychosis
Schizophrenia

Access to Document

10.1016/B978-0-12-813201-2.00006-5

Cite this

@inbook{3e6eb10805ef41c689163558709fa566,

title = "Familial high risk and high-risk studies",

abstract = "A prominent risk factor for psychosis is its high heritability. This offers us a means to identify potential biomarkers of risk and resilience by focusing on people who are at familial high risk, but are currently free of both illness and medication. The genetic underpinnings of this risk allow us to gain a more mechanistic understanding, which may better guide therapeutic development and prevention strategies. Here, we summarize two prospective longitudinal familial high-risk studies: the Edinburgh High Risk Study of schizophrenia and the Bipolar Family Study. This work highlights the complex interactions between molecular mechanisms and environmental circumstances in the generation and perpetuation of psychosis.",

keywords = "Bipolar affective disorder, Cohort study, Familial high risk, Genetic risk, Longitudinal, MRI, Psychosis, Schizophrenia",

author = "Liana Romaniuk and Chan, {Stella W.Y.} and Alix Macdonald and Sussmann, {Jessika E.} and McIntosh, {Andrew M.} and Whalley, {Heather C.} and Lawrie, {Stephen M.}",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-813201-2.00006-5",

language = "English",

isbn = "9780128132029",

pages = "101--117",

booktitle = "Risk Factors for Psychosis",

publisher = "Elsevier",

address = "Netherlands",

}

TY - CHAP

T1 - Familial high risk and high-risk studies

AU - Romaniuk, Liana

AU - Chan, Stella W.Y.

AU - Macdonald, Alix

AU - Sussmann, Jessika E.

AU - McIntosh, Andrew M.

AU - Whalley, Heather C.

AU - Lawrie, Stephen M.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - A prominent risk factor for psychosis is its high heritability. This offers us a means to identify potential biomarkers of risk and resilience by focusing on people who are at familial high risk, but are currently free of both illness and medication. The genetic underpinnings of this risk allow us to gain a more mechanistic understanding, which may better guide therapeutic development and prevention strategies. Here, we summarize two prospective longitudinal familial high-risk studies: the Edinburgh High Risk Study of schizophrenia and the Bipolar Family Study. This work highlights the complex interactions between molecular mechanisms and environmental circumstances in the generation and perpetuation of psychosis.

AB - A prominent risk factor for psychosis is its high heritability. This offers us a means to identify potential biomarkers of risk and resilience by focusing on people who are at familial high risk, but are currently free of both illness and medication. The genetic underpinnings of this risk allow us to gain a more mechanistic understanding, which may better guide therapeutic development and prevention strategies. Here, we summarize two prospective longitudinal familial high-risk studies: the Edinburgh High Risk Study of schizophrenia and the Bipolar Family Study. This work highlights the complex interactions between molecular mechanisms and environmental circumstances in the generation and perpetuation of psychosis.

KW - Bipolar affective disorder

KW - Cohort study

KW - Familial high risk

KW - Genetic risk

KW - Longitudinal

KW - MRI

KW - Psychosis

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85142106030&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-813201-2.00006-5

DO - 10.1016/B978-0-12-813201-2.00006-5

M3 - Chapter

AN - SCOPUS:85142106030

SN - 9780128132029

SP - 101

EP - 117

BT - Risk Factors for Psychosis

PB - Elsevier

ER -

Familial high risk and high-risk studies

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Other files and links

Fingerprint

Cite this