Fast and furious: The neutrophil and its armamentarium in health and disease

Mieke Metzemaekers, Bert Malengier-Devlies, Mieke Gouwy, Lien De Somer, Fernando de Queiroz Cunha, Ghislain Opdenakker, Paul Proost

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Neutrophils are powerful effector cells leading the first wave of acute host-protective responses. These innate leukocytes are endowed with oxidative and nonoxidative defence mechanisms, and play well-established roles in fighting invading pathogens. With microbicidal weaponry largely devoid of specificity and an all-too-well recognized toxicity potential, collateral damage may occur in neutrophil-rich diseases. However, emerging evidence suggests that neutrophils are more versatile, heterogeneous, and sophisticated cells than initially thought. At the crossroads of innate and adaptive immunity, neutrophils demonstrate their multifaceted functions in infectious and noninfectious pathologies including cancer, autoinflammation, and autoimmune diseases. Here, we discuss the kinetics of neutrophils and their products of activation from bench to bedside during health and disease, and provide an overview of the versatile functions of neutrophils as key modulators of immune responses and physiological processes. We focus specifically on those activities and concepts that have been validated with primary human cells.

Original languageEnglish
Pages (from-to)1537-1606
Number of pages70
JournalMedicinal research reviews
Volume43
Issue number5
DOIs
Publication statusPublished - Sept 2023

Keywords / Materials (for Non-textual outputs)

  • Humans
  • Neutrophils
  • Immunity, Innate
  • Adaptive Immunity
  • Neoplasms
  • Anti-Infective Agents
  • Inflammation

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