Abstract / Description of output
Under certain circumstances, X-linked loci are expected to experience more adaptive substitutions than similar autosomal loci. To look for evidence of faster-X evolution, we analyzed the evolutionary rates of coding sequences in two sets of Drosophila species, the melanogaster and pseudoobscura clades, using whole genome sequences. One of these, the pseudoobscura clade, contains a centric fusion between the ancestral X chromosome and the autosomal arm homologous to 3L in D. melanogaster. This offers an opportunity to study the same loci in both an X-linked and an autosomal context, and to compare these loci to those that are only X-linked or only autosomal. We therefore investigated these clades for evidence of faster-X evolution with respect to nonsynonymous substitutions, finding mixed results. Overall, there was consistent evidence for a faster-X effect in the melanogaster clade, but not in the pseudoobscura clade, except for the comparison between D. pseudoobscura and its close relative, D. persimilis. An analysis of polymorphism data on a set of genes from D. pseudoobscura that evolve rapidly with respect to their protein sequences revealed no evidence for a faster-X effect with respect to adaptive protein sequence evolution; their rapid evolution is instead largely attributable to lower selective constraints. Faster-X evolution in the melanogaster clade was not related to male-biased gene expression; surprisingly, however, female-biased genes showed evidence for faster-X effects.
Original language | English |
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Pages (from-to) | 2968-2982 |
Journal | Genome Biology and Evolution |
Volume | 6 |
Issue number | 10 |
DOIs | |
Publication status | Published - 15 Oct 2014 |
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Data from: Faster-X Effects in two Drosophila lineages
Ávila, V. (Creator), Marion De Procé, S. (Creator), Campos, J. L. (Creator), Borthwick, H. (Creator), Charlesworth, B. (Creator) & Betancourt, A. J. (Creator), Dryad, 28 Oct 2014
DOI: 10.5061/dryad.3hh83, http://datadryad.org/stash/dataset/doi:10.5061/dryad.3hh83
Dataset