FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans

Mariam Molokhia; Manuela Fanciulli; Enrico Petretto; Alan Leslie Patrick; Paul McKeigue; Amy L. Roberts; Tim J. Vyse; Tim Aitman

doi:10.1093/rheumatology/keq456

FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans

Mariam Molokhia^*, Manuela Fanciulli, Enrico Petretto, Alan Leslie Patrick, Paul McKeigue, Amy L. Roberts, Tim J. Vyse, Tim Aitman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Methods. We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE and SLE nephritis within a case-control collection of 134 cases of SLE (37 with SLE nephritis) and 589 population controls of mainly Afro-Caribbean descent resident in Trinidad.

Results. We found a significant difference in copy number FCGR3B distribution between unadmixed African and European UK cohorts, with 27 (29%) vs 3 (5%) for those with low (0 or 1) copy FCGR3B, respectively, P = 0.002. In a Trinidadian SLE case-control study, low FCGR3B CNV was associated with SLE risk 1.7 (95% CI 1.1, 2.8), P = 0.02, which remained after adjustment for African genetic ancestry; odds ratios (ORs) 1.7 (95% CI 1.0, 2.8), P = 0.04.

Conclusion. Our studies suggest that FCGR3B low copy number is associated with SLE risk in Afro-Caribbean populations independently of CNV due to African ancestry.

Original language	English
Pages (from-to)	1206-1210
Number of pages	5
Journal	Rheumatology
Volume	50
Issue number	7
DOIs	https://doi.org/10.1093/rheumatology/keq456
Publication status	Published - Jul 2011

Keywords / Materials (for Non-textual outputs)

African
AUTOIMMUNITY
Admixture
SUSCEPTIBILITY
HUMAN GENOME
POLYMORPHISM
SLE
GENE
PREDISPOSES
CCL3L1
EXPRESSION
POPULATION
Copy number variation
DISEASE
FCGR3B

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10.1093/rheumatology/keq456

FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans
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http://rheumatology.oxfordjournals.org/content/50/7/1206

Cite this

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title = "FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans",

abstract = "Methods. We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE and SLE nephritis within a case-control collection of 134 cases of SLE (37 with SLE nephritis) and 589 population controls of mainly Afro-Caribbean descent resident in Trinidad.Results. We found a significant difference in copy number FCGR3B distribution between unadmixed African and European UK cohorts, with 27 (29%) vs 3 (5%) for those with low (0 or 1) copy FCGR3B, respectively, P = 0.002. In a Trinidadian SLE case-control study, low FCGR3B CNV was associated with SLE risk 1.7 (95% CI 1.1, 2.8), P = 0.02, which remained after adjustment for African genetic ancestry; odds ratios (ORs) 1.7 (95% CI 1.0, 2.8), P = 0.04.Conclusion. Our studies suggest that FCGR3B low copy number is associated with SLE risk in Afro-Caribbean populations independently of CNV due to African ancestry.",

keywords = "African, AUTOIMMUNITY, Admixture, SUSCEPTIBILITY, HUMAN GENOME, POLYMORPHISM, SLE, GENE, PREDISPOSES, CCL3L1, EXPRESSION, POPULATION, Copy number variation, DISEASE, FCGR3B",

author = "Mariam Molokhia and Manuela Fanciulli and Enrico Petretto and Patrick, {Alan Leslie} and Paul McKeigue and Roberts, {Amy L.} and Vyse, {Tim J.} and Tim Aitman",

year = "2011",

month = jul,

doi = "10.1093/rheumatology/keq456",

language = "English",

volume = "50",

pages = "1206--1210",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

number = "7",

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T1 - FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans

AU - Molokhia, Mariam

AU - Fanciulli, Manuela

AU - Petretto, Enrico

AU - Patrick, Alan Leslie

AU - McKeigue, Paul

AU - Roberts, Amy L.

AU - Vyse, Tim J.

AU - Aitman, Tim

PY - 2011/7

Y1 - 2011/7

N2 - Methods. We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE and SLE nephritis within a case-control collection of 134 cases of SLE (37 with SLE nephritis) and 589 population controls of mainly Afro-Caribbean descent resident in Trinidad.Results. We found a significant difference in copy number FCGR3B distribution between unadmixed African and European UK cohorts, with 27 (29%) vs 3 (5%) for those with low (0 or 1) copy FCGR3B, respectively, P = 0.002. In a Trinidadian SLE case-control study, low FCGR3B CNV was associated with SLE risk 1.7 (95% CI 1.1, 2.8), P = 0.02, which remained after adjustment for African genetic ancestry; odds ratios (ORs) 1.7 (95% CI 1.0, 2.8), P = 0.04.Conclusion. Our studies suggest that FCGR3B low copy number is associated with SLE risk in Afro-Caribbean populations independently of CNV due to African ancestry.

AB - Methods. We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE and SLE nephritis within a case-control collection of 134 cases of SLE (37 with SLE nephritis) and 589 population controls of mainly Afro-Caribbean descent resident in Trinidad.Results. We found a significant difference in copy number FCGR3B distribution between unadmixed African and European UK cohorts, with 27 (29%) vs 3 (5%) for those with low (0 or 1) copy FCGR3B, respectively, P = 0.002. In a Trinidadian SLE case-control study, low FCGR3B CNV was associated with SLE risk 1.7 (95% CI 1.1, 2.8), P = 0.02, which remained after adjustment for African genetic ancestry; odds ratios (ORs) 1.7 (95% CI 1.0, 2.8), P = 0.04.Conclusion. Our studies suggest that FCGR3B low copy number is associated with SLE risk in Afro-Caribbean populations independently of CNV due to African ancestry.

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KW - Admixture

KW - SUSCEPTIBILITY

KW - HUMAN GENOME

KW - POLYMORPHISM

KW - SLE

KW - GENE

KW - PREDISPOSES

KW - CCL3L1

KW - EXPRESSION

KW - POPULATION

KW - Copy number variation

KW - DISEASE

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DO - 10.1093/rheumatology/keq456

M3 - Article

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VL - 50

SP - 1206

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JO - Rheumatology

JF - Rheumatology

IS - 7

ER -

FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans

Abstract

Keywords / Materials (for Non-textual outputs)

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