Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka

D. W. Knipe; C. Jayasumana; S. Siribaddana; C. Priyadarshana; M. Pearson; D. Gunnell; C. Metcalfe; M. N. Tzatzarakis; A. M. Tsatsakis

doi:10.1016/j.envres.2016.02.011

Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka

D. W. Knipe^*, C. Jayasumana, S. Siribaddana, C. Priyadarshana, M. Pearson, D. Gunnell, C. Metcalfe, M. N. Tzatzarakis, A. M. Tsatsakis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Measuring chronic pesticide exposure is important in order to investigate the associated health effects. Traditional biological samples (blood/urine) are difficult to collect, store and transport in large epidemiological studies in settings such as rural Asia. We assessed the acceptability of collecting hair samples from a rural Sri Lankan population and found that this method of data collection was feasible. We also assessed the level of non-specific metabolites (DAPS) of organophosphate pesticides in the hair samples. The median concentration (pg/mg) of each DAP was: diethyl phosphate: 83.3 (IQI 56.0, 209.4); diethyl thiophosphate: 34.7 (IQI 13.8, 147.9); diethyl dithiophosphate: 34.5 (IQI 23.4, 55.2); and dimethyl phosphate: 3 (IQI 3, 109.7). Total diethylphosphates were recovered in >80% of samples and were positively correlated with self-reported pesticide exposure.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	Environmental Research
Volume	147
DOIs	https://doi.org/10.1016/j.envres.2016.02.011
Publication status	Published - 1 May 2016

Keywords / Materials (for Non-textual outputs)

Chronic exposure
Dialkylphosphates metabolites
Hair
Pesticides
Sri Lanka

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10.1016/j.envres.2016.02.011

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title = "Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka",

abstract = "Measuring chronic pesticide exposure is important in order to investigate the associated health effects. Traditional biological samples (blood/urine) are difficult to collect, store and transport in large epidemiological studies in settings such as rural Asia. We assessed the acceptability of collecting hair samples from a rural Sri Lankan population and found that this method of data collection was feasible. We also assessed the level of non-specific metabolites (DAPS) of organophosphate pesticides in the hair samples. The median concentration (pg/mg) of each DAP was: diethyl phosphate: 83.3 (IQI 56.0, 209.4); diethyl thiophosphate: 34.7 (IQI 13.8, 147.9); diethyl dithiophosphate: 34.5 (IQI 23.4, 55.2); and dimethyl phosphate: 3 (IQI 3, 109.7). Total diethylphosphates were recovered in >80% of samples and were positively correlated with self-reported pesticide exposure.",

keywords = "Chronic exposure, Dialkylphosphates metabolites, Hair, Pesticides, Sri Lanka",

author = "Knipe, {D. W.} and C. Jayasumana and S. Siribaddana and C. Priyadarshana and M. Pearson and D. Gunnell and C. Metcalfe and Tzatzarakis, {M. N.} and Tsatsakis, {A. M.}",

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doi = "10.1016/j.envres.2016.02.011",

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AU - Knipe, D. W.

AU - Jayasumana, C.

AU - Siribaddana, S.

AU - Priyadarshana, C.

AU - Pearson, M.

AU - Gunnell, D.

AU - Metcalfe, C.

AU - Tzatzarakis, M. N.

AU - Tsatsakis, A. M.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Measuring chronic pesticide exposure is important in order to investigate the associated health effects. Traditional biological samples (blood/urine) are difficult to collect, store and transport in large epidemiological studies in settings such as rural Asia. We assessed the acceptability of collecting hair samples from a rural Sri Lankan population and found that this method of data collection was feasible. We also assessed the level of non-specific metabolites (DAPS) of organophosphate pesticides in the hair samples. The median concentration (pg/mg) of each DAP was: diethyl phosphate: 83.3 (IQI 56.0, 209.4); diethyl thiophosphate: 34.7 (IQI 13.8, 147.9); diethyl dithiophosphate: 34.5 (IQI 23.4, 55.2); and dimethyl phosphate: 3 (IQI 3, 109.7). Total diethylphosphates were recovered in >80% of samples and were positively correlated with self-reported pesticide exposure.

AB - Measuring chronic pesticide exposure is important in order to investigate the associated health effects. Traditional biological samples (blood/urine) are difficult to collect, store and transport in large epidemiological studies in settings such as rural Asia. We assessed the acceptability of collecting hair samples from a rural Sri Lankan population and found that this method of data collection was feasible. We also assessed the level of non-specific metabolites (DAPS) of organophosphate pesticides in the hair samples. The median concentration (pg/mg) of each DAP was: diethyl phosphate: 83.3 (IQI 56.0, 209.4); diethyl thiophosphate: 34.7 (IQI 13.8, 147.9); diethyl dithiophosphate: 34.5 (IQI 23.4, 55.2); and dimethyl phosphate: 3 (IQI 3, 109.7). Total diethylphosphates were recovered in >80% of samples and were positively correlated with self-reported pesticide exposure.

KW - Chronic exposure

KW - Dialkylphosphates metabolites

KW - Hair

KW - Pesticides

KW - Sri Lanka

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DO - 10.1016/j.envres.2016.02.011

M3 - Article

AN - SCOPUS:84958150595

SN - 0013-9351

VL - 147

SP - 207

EP - 211

JO - Environmental Research

JF - Environmental Research

ER -

Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka

Abstract

Keywords / Materials (for Non-textual outputs)

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