Feasibility of radiation dose reduction using AIDR-3D in dynamic pulmonary CT perfusion.

Saeed Mirsadraee, Nick Weir, Stuart Connolly, J T Murchison, John H. Reid, Nikhil Hirani, Martin Connell, Edwin Jacques Rudolph van Beek

Research output: Contribution to journalArticlepeer-review


AIM: To assess the feasibility of radiation dose reduction with adaptive iterative dose reduction (AIDR-6 3D) reconstruction in dynamic pulmonary CT perfusion.

MATERIALS AND METHODS: CTP examinations of 10 patients acquired at 100 kVp/50 mAs were reconstructed with filtered back projection (FBP) and AIDR-3D. Artificial noise was added to raw data (pre-reconstruction projection data) to simulate lower tube current scanning. Radiodensity (in Hounsfield units), noise, and perfusion values were compared.

RESULTS: There was no significant difference in noise between the full and simulated reduced tube current with AIDR-3D reconstruction (p = 1). There was significantly lower noise in lung tissue with AIDR-3D images when compared to reconstructions without AIDR-3D (p = 0.005) and no significant change in the radiodensity (p = 1; mean difference <6 HU). Mean perfusion values increased significantly at lower tube currents (25 and 12.5 mAs), compared to 50 mAs (p = 0.005). This effect was significantly greater in larger patients compared to thin patients.

CONCLUSION: AIDR-3D produced significantly lower noise images than FBP-based algorithms and maintained consistent noise levels in lung at 12.5 mAs, indicating this algorithm is suitable for reduced dose lung perfusion imaging. Iterative reconstruction allows significant radiation dose reduction of up to fourfold in smaller patients, and up to twofold in the medium/large size patients. The increase in perfusion values at 25% simulated tube currents is attributed to attenuation bias.

Original languageEnglish
Pages (from-to)844–851
JournalClinical Radiology
Issue number8
Early online date21 May 2015
Publication statusPublished - Aug 2015


Dive into the research topics of 'Feasibility of radiation dose reduction using AIDR-3D in dynamic pulmonary CT perfusion.'. Together they form a unique fingerprint.

Cite this