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Abstract
The early life environment programmes cortical architecture and cognition across the life course. A measure of cortical organisation that integrates information from multi-modal MRI and is unbound by arbitrary parcellations has proven elusive, which hampers efforts to uncover the perinatal origins of cortical health. Here, we use the Vogt-Bailey index to provide a fine-grained description of regional homogeneities and sharp variations in cortical microstructure based on feature gradients, and we investigate the impact of being born preterm on cortical development at term-equivalent age. Compared to term-born controls, preterm infants have a homogeneous microstructure in temporal and occipital lobes, and the medial parietal, cingulate, and frontal cortices, compared with term infants. These observations replicated across two independent datasets and were robust to differences that remain in the data after matching samples and alignment of processing and quality control strategies. We conclude that cortical microstructural architecture is altered in preterm infants in a spatially distributed rather than localised fashion.
Keywords: feature similarity gradients, neonatal brain, preterm birth, MRI, neonatal cortex
Keywords: feature similarity gradients, neonatal brain, preterm birth, MRI, neonatal cortex
Original language | English |
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Journal | Human Brain Mapping |
DOIs | |
Publication status | Published - 15 Mar 2024 |
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Dive into the research topics of 'Feature similarity gradients detect alterations in the neonatal cortex associated with preterm birth'. Together they form a unique fingerprint.Projects
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Preterm birth, Neurodevelopment and Cognition in Children: Causal Evidence and Mechanisms
1/11/22 → 31/10/27
Project: Research