FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation

J Dubrulle, M J McGrew, O Pourquié

Research output: Contribution to journalArticlepeer-review

Abstract

Vertebrate segmentation requires a molecular oscillator, the segmentation clock, acting in presomitic mesoderm (PSM) cells to set the pace at which segmental boundaries are laid down. However, the signals that position each boundary remain unclear. Here, we report that FGF8 which is expressed in the posterior PSM, generates a moving wavefront at which level both segment boundary position and axial identity become determined. Furthermore, by manipulating boundary position in the chick embryo, we show that Hox gene expression is maintained in the appropriately numbered somite rather than at an absolute axial position. These results implicate FGF8 in ensuring tight coordination of the segmentation process and spatiotemporal Hox gene activation.
Original languageEnglish
Pages (from-to)219-32
Number of pages14
JournalCell
Volume106
Issue number2
Publication statusPublished - 27 Jul 2001

Keywords

  • Animals
  • Avian Proteins
  • Basic Helix-Loop-Helix Transcription Factors
  • Biological Clocks
  • Cell Count
  • Cell Size
  • Chick Embryo
  • DNA-Binding Proteins
  • Fetal Proteins
  • Fibroblast Growth Factor 8
  • Fibroblast Growth Factors
  • Gene Expression
  • Gene Expression Regulation, Developmental
  • Genes, Homeobox
  • Homeodomain Proteins
  • Immunohistochemistry
  • In Situ Hybridization
  • Microspheres
  • Models, Biological
  • Proteins
  • RNA, Messenger
  • Signal Transduction
  • Somites
  • T-Box Domain Proteins
  • Transcriptional Activation

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