Fine mapping a locus controlling leg morphology in the domestic dog

P Quignon, J J Schoenebeck, K Chase, H G Parker, D S Mosher, G S Johnson, K G Lark, E A Ostrander

Research output: Contribution to journalArticlepeer-review

Abstract

The domestic dog offers a remarkable opportunity to disentangle the genetics of complex phenotypes. Here, we explore a locus, previously identified in the Portuguese water dog (PWD), associated with PC2, a morphological principal component characterized as leg width versus leg length. The locus was initially mapped to a region of 26 Mb on canine chromosome 12 (CFA12) following a genome-wide scan. Subsequent and extensive genotyping of single-nucleotide polymorphisms (SNPs) and haplotype analysis in both the PWD and selected breeds representing phenotypic extremes of PC2 reduced the region from 26 Mb to 500 kb. The proximity of the critical interval to two collagen genes suggests that the phenotype may be controlled by cis-acting mechanisms.
Original languageEnglish
Pages (from-to)327-33
Number of pages7
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume74
DOIs
Publication statusPublished - 2009

Keywords

  • Animals
  • Chromosome Mapping
  • Dogs
  • Extremities
  • Genetic Association Studies
  • Genome-Wide Association Study
  • Haplotypes
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci

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