Fine mapping a locus controlling leg morphology in the domestic dog

P Quignon; J J Schoenebeck; K Chase; H G Parker; D S Mosher; G S Johnson; K G Lark; E A Ostrander

doi:10.1101/sqb.2009.74.009

Fine mapping a locus controlling leg morphology in the domestic dog

P Quignon, J J Schoenebeck, K Chase, H G Parker, D S Mosher, G S Johnson, K G Lark, E A Ostrander

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The domestic dog offers a remarkable opportunity to disentangle the genetics of complex phenotypes. Here, we explore a locus, previously identified in the Portuguese water dog (PWD), associated with PC2, a morphological principal component characterized as leg width versus leg length. The locus was initially mapped to a region of 26 Mb on canine chromosome 12 (CFA12) following a genome-wide scan. Subsequent and extensive genotyping of single-nucleotide polymorphisms (SNPs) and haplotype analysis in both the PWD and selected breeds representing phenotypic extremes of PC2 reduced the region from 26 Mb to 500 kb. The proximity of the critical interval to two collagen genes suggests that the phenotype may be controlled by cis-acting mechanisms.

Original language	English
Pages (from-to)	327-33
Number of pages	7
Journal	Cold Spring Harbor Symposia on Quantitative Biology
Volume	74
DOIs	https://doi.org/10.1101/sqb.2009.74.009
Publication status	Published - 2009

Keywords / Materials (for Non-textual outputs)

Animals
Chromosome Mapping
Dogs
Extremities
Genetic Association Studies
Genome-Wide Association Study
Haplotypes
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci

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10.1101/sqb.2009.74.009

Fine mapping a locus controlling leg morphology in the domestic dog
Copyright © 2009, Cold Spring Harbor Laboratory Press
Accepted author manuscript, 1.49 MB

http://symposium.cshlp.org/content/74/327

Cite this

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title = "Fine mapping a locus controlling leg morphology in the domestic dog",

abstract = "The domestic dog offers a remarkable opportunity to disentangle the genetics of complex phenotypes. Here, we explore a locus, previously identified in the Portuguese water dog (PWD), associated with PC2, a morphological principal component characterized as leg width versus leg length. The locus was initially mapped to a region of 26 Mb on canine chromosome 12 (CFA12) following a genome-wide scan. Subsequent and extensive genotyping of single-nucleotide polymorphisms (SNPs) and haplotype analysis in both the PWD and selected breeds representing phenotypic extremes of PC2 reduced the region from 26 Mb to 500 kb. The proximity of the critical interval to two collagen genes suggests that the phenotype may be controlled by cis-acting mechanisms.",

keywords = "Animals, Chromosome Mapping, Dogs, Extremities, Genetic Association Studies, Genome-Wide Association Study, Haplotypes, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci",

author = "P Quignon and Schoenebeck, {J J} and K Chase and Parker, {H G} and Mosher, {D S} and Johnson, {G S} and Lark, {K G} and Ostrander, {E A}",

year = "2009",

doi = "10.1101/sqb.2009.74.009",

language = "English",

volume = "74",

pages = "327--33",

journal = "Cold Spring Harbor Symposia on Quantitative Biology",

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T1 - Fine mapping a locus controlling leg morphology in the domestic dog

AU - Quignon, P

AU - Schoenebeck, J J

AU - Chase, K

AU - Parker, H G

AU - Mosher, D S

AU - Johnson, G S

AU - Lark, K G

AU - Ostrander, E A

PY - 2009

Y1 - 2009

N2 - The domestic dog offers a remarkable opportunity to disentangle the genetics of complex phenotypes. Here, we explore a locus, previously identified in the Portuguese water dog (PWD), associated with PC2, a morphological principal component characterized as leg width versus leg length. The locus was initially mapped to a region of 26 Mb on canine chromosome 12 (CFA12) following a genome-wide scan. Subsequent and extensive genotyping of single-nucleotide polymorphisms (SNPs) and haplotype analysis in both the PWD and selected breeds representing phenotypic extremes of PC2 reduced the region from 26 Mb to 500 kb. The proximity of the critical interval to two collagen genes suggests that the phenotype may be controlled by cis-acting mechanisms.

AB - The domestic dog offers a remarkable opportunity to disentangle the genetics of complex phenotypes. Here, we explore a locus, previously identified in the Portuguese water dog (PWD), associated with PC2, a morphological principal component characterized as leg width versus leg length. The locus was initially mapped to a region of 26 Mb on canine chromosome 12 (CFA12) following a genome-wide scan. Subsequent and extensive genotyping of single-nucleotide polymorphisms (SNPs) and haplotype analysis in both the PWD and selected breeds representing phenotypic extremes of PC2 reduced the region from 26 Mb to 500 kb. The proximity of the critical interval to two collagen genes suggests that the phenotype may be controlled by cis-acting mechanisms.

KW - Animals

KW - Chromosome Mapping

KW - Dogs

KW - Extremities

KW - Genetic Association Studies

KW - Genome-Wide Association Study

KW - Haplotypes

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

U2 - 10.1101/sqb.2009.74.009

DO - 10.1101/sqb.2009.74.009

M3 - Article

C2 - 19717540

SN - 1943-4456

VL - 74

SP - 327

EP - 333

JO - Cold Spring Harbor Symposia on Quantitative Biology

JF - Cold Spring Harbor Symposia on Quantitative Biology

ER -

Fine mapping a locus controlling leg morphology in the domestic dog

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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