Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase

Tomomasa Yokomizo, Elaine Dzierzak

Research output: Contribution to journalComment/debatepeer-review

Abstract

Homeostasis of hematopoietic stem cells (HSCs) is a tightly regulated process, controlled by intrinsic and extrinsic signals. Although a variety of molecules involved in HSC maintenance and self-renewal are known, it remains unclear how robust HSC homeostasis is achieved. In this issue of Genes & Development, Rathinam and colleagues (992-997) report a new player in HSC homeostasis, c-Cbl ubiquitin ligase. They show that this E3 ubiquitin ligase acts as a negative regulator of cytokine signaling.
Original languageEnglish
Pages (from-to)960-3
Number of pages4
JournalGenes & Development
Volume22
Issue number8
DOIs
Publication statusPublished - 15 Apr 2008

Keywords

  • Animals
  • Bone Marrow Cells
  • Cytokines
  • Hematopoietic Stem Cells
  • Homeostasis
  • Mice
  • Proto-Oncogene Proteins c-cbl
  • Signal Transduction

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