Abstract / Description of output
Homeostasis of hematopoietic stem cells (HSCs) is a tightly regulated process, controlled by intrinsic and extrinsic signals. Although a variety of molecules involved in HSC maintenance and self-renewal are known, it remains unclear how robust HSC homeostasis is achieved. In this issue of Genes & Development, Rathinam and colleagues (992-997) report a new player in HSC homeostasis, c-Cbl ubiquitin ligase. They show that this E3 ubiquitin ligase acts as a negative regulator of cytokine signaling.
Original language | English |
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Pages (from-to) | 960-3 |
Number of pages | 4 |
Journal | Genes & Development |
Volume | 22 |
Issue number | 8 |
DOIs |
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Publication status | Published - 15 Apr 2008 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Bone Marrow Cells
- Cytokines
- Hematopoietic Stem Cells
- Homeostasis
- Mice
- Proto-Oncogene Proteins c-cbl
- Signal Transduction