Abstract
In using nanomaterials for advanced photodynamic therapy, it is important to improve surface modification to increase stability, minimize non-specific loss of drugs in blood circulation, ehance the photostability of photosensitizers, and achieve highly efficient intracellular uptake. In this report, we for the first time covalently conjugate photosensitizer Chlorin e6 (Ce6) to polyethyleneglycol modified layered double hydroxides and produe hybrid nanoflakes. These nanoflakes display many superior characteristics and lead to excellent in vivo photodynamic therapeutic efficiency and safety profiles.
Original language | English |
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Pages (from-to) | 2339-2342 |
Journal | Chemical Communications |
Early online date | 27 Jan 2017 |
DOIs | |
Publication status | Published - 2017 |