First case report of cutaneous sporotrichosis (Sporothrix species) in a cat in the UK

Nikoleta Makri, Gavin Paterson, Fiona Gregge, Catriona Urquhart, Tim Nuttall

Research output: Contribution to journalArticlepeer-review

Abstract

Case summary
A 12-year-old female-neutered, indoor-outdoor domestic longhaired cat presented with frequent sneezing and a nodular, suppurative lesion on her dorsal nose. Histopathological examination revealed a fungal granuloma. PCR and sequencing of the ribosomal internal transcribed spacers (ITS) regions (ITS-F and ITS-R) confirmed an infection with a Sporothrix species. Further sequencing of the beta-tubulin and calmodulin genes confirmed S. humicola, which lies within the S. pallida complex. The cat had concurrent diabetes mellitus, which responded to insulin therapy and diet. Oral itraconazole at 10 mg/kg PO q24h resulted in resolution of the lesions after 12 months. Treatment was well tolerated.
Relevance and Novel Information
This is the first report of sporotrichosis in a cat in the UK and only the fifth worldwide involving the S. pallida complex. Clinicians, pathologists and microbiologists need to be aware of the potential of Sporothrix infections in the UK and the ability of S. pallida complex to cause opportunistic infections. Molecular techniques can achieve rapid and accurate identification of rare fungal organisms. A precise diagnosis with molecular testing can provide information regarding prognosis, treatment and zoonotic implications.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Feline Medicine and Surgery Open Reports
Volume6
Early online date14 Feb 2020
DOIs
Publication statusE-pub ahead of print - 14 Feb 2020

Keywords

  • Cutaneous mycosis
  • molecular identification
  • Sporothrix pallida
  • Sporothrix species
  • sporotrichosis

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