First investigation of the prevalence of parvoviruses in slaughterhouse pigs and genomic characterization of Ungulate copiparvovirus 2 in Vietnam

Nguyen Thi Dieu Thuy, T. Nguyen Trung, Tran Quoc Dung, Do Vo Anh Khoa, Thi Ngoc Thuy, Tanja Opriessnig

Research output: Contribution to journalArticlepeer-review

Abstract

Ungulate protoparvovirus 1, also known as porcine parvovirus 1 (PPV1), is considered to be one of the major causes of reproductive failure in pig breeding herds. In addition, in pigs, other parvoviruses have also been identified, including Ungulate tetraparvovirus 3 or PPV2, Ungulate tetraparvovirus 2 or PPV3, and Ungulate copiparvovirus 2 or PPV4 but their significance for pigs is unknown. In the present study, the prevalence of PPV1-4 was investigated using a total of 231 lung and serum samples collected from slaughter houses in 13
provinces throughout Vietnam. The overall prevalence was 54.5% (126/231) for PPV1, 28.0% (65/231) for PPV2, 17.7% (41/231) for PPV3, and 7.8% (18/231) for PPV4. While PPV1 and PPV2 appeared in 11/13 provinces, PPV4 was detected in only 3/13 provinces. PPV1, PPV2 and PPV3 co-circulation was frequently observed with PPV1/PPV2 co-infection,predominating with 20.8% (48/231). All four PPVs were only detected together in one sample from Thua Thien Hue. Three nearly complete PPV4 genomes of 5,453 bp in size were obtained
and deposited in GenBank. Genomic alignment and comparison of the three sequences showed high identities at both the nucleotide (99.5-99.6%) and the deducted amino acid levels (99.6-99.9%) of open reading frames 1-3 and also with Vietnamese or Chinese strains (98.9-99.3% and 99.4-99.7%, respectively). Phylogenetic analysis further confirmed a close relationship between Vietnamese and Chinese PPV4 strains. These results are the first to report the prevalence of PPV1, PPV2, PPV3, and PPV4 and nearly complete genomic sequences of PPV4
in pigs from slaughterhouses in Vietnam.
Original languageEnglish
JournalArchives of Virology
Early online date12 Jan 2021
DOIs
Publication statusE-pub ahead of print - 12 Jan 2021

Keywords

  • Porcine parvovirus
  • PPV1
  • PPV2
  • PPV3
  • PPV4
  • Vietnam
  • Prevalence
  • Coinfections
  • PPV4 sequence

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