Flexible, Phase-Transfer Catalyzed Approaches to 4-Substituted Prolines

Heather J. Johnston, Fergus S. Mcwhinnie, Felicetta Landi, Alison N. Hulme

Research output: Contribution to journalArticlepeer-review

Abstract

A range of 4-substituted prolines can be rapidly synthesized from a protected glycine Schiff base in only four steps and in 27–55% overall yield. Phase transfer catalysis allows direct access to both enantiomeric series, and the relative stereochemistry at the 4-position is readily controlled (>10:1 dr) through the choice of hydrogenation conditions.
Original languageEnglish
Pages (from-to)4778–4781
JournalOrganic letters
Volume16
Issue number18
Early online date5 Sep 2014
DOIs
Publication statusPublished - 19 Sep 2014

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