Fluorescence correlation spectroscopy: Lead discovery by miniaturized HTS

M. Auer, K.J. Moore, F.J. Meyer-Almes, R. Guenther, A.J. Pope, K.A. Stoeckli

Research output: Contribution to journalArticlepeer-review


Miniaturized high-throughput screening offers great promise for increasing the productivity of the pharmaceutical drug discovery process. By monitoring interactions of single molecules in femtoliter volumes, fluorescence correlation spectroscopy (FCS) offers the highest potential as the detection technique in the nanoscale. The authors () summarize the current status of practical experiences with FCS assays for HTS and explore the scope for further developments. Copyright (C) 1998 Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)457-465
Number of pages9
JournalInternational Journal of Immunopharmacology
Issue number2
Publication statusPublished - 1 Jan 1999


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