Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Ramon Subiros-funosas, Vivian Cheuk Lam Ho, Nicole D. Barth, Lorena Mendive-tapia, Morena Pappalardo, Xavier Barril, Ruoyu Ma, Cheng-bin Zhang, Bin-zhi Qian, Miquel Sintes, Ouldouz Ghashghaei, Rodolfo Lavilla, Marc Vendrell

Research output: Contribution to journalArticlepeer-review

Abstract

Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.
Original languageEnglish
Pages (from-to)1368-1374
JournalChemical Science
Volume11
Issue number5
Early online date18 Dec 2019
DOIs
Publication statusE-pub ahead of print - 18 Dec 2019

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