Projects per year
We present FM-Sim, a domain-specific simulator for defining and simulating fluorescence microscopy assays. Experimental protocols as performed in vitro may be defined in the simulator. The defined protocols then interact with a computational model of presynaptic behaviour in rodent central nervous system neurons, allowing simulation of fluorescent responses to varying stimuli. Rate parameters of the model may be obtained using Bayesian inference functions integrated into the simulator, given experimental fluorescence observations of the protocol performed in vitro as training data. These trained protocols allow for predictive in silico modelling of potential experimental outcomes prior to time-consuming and expensive in vitro studies.
|Title of host publication||Computational Methods in Systems Biology|
|Subtitle of host publication||12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings|
|Publisher||Springer International Publishing|
|Number of pages||4|
|Publication status||Published - 2014|
|Event||Third International Workshop on Hybrid Systems Biology - Vienna, Austria|
Duration: 23 Jul 2014 → 24 Jul 2014
|Name||Lecture Notes in Computer Science|
|Workshop||Third International Workshop on Hybrid Systems Biology|
|Period||23/07/14 → 24/07/14|
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- 1 Finished
1/01/12 → 31/12/16