Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

M S Duxbury, H Ito, M J Zinner, S W Ashley, E E Whang

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Inadequate or inappropriate cell-substrate contact triggers a subset of apoptotic cell death, termed anoikis. Resistance to anoikis is a characteristic of malignant cells that is associated with increased tumorigenesis and metastasis. Focal adhesion kinase (FAK) is an important regulator of cell survival and migration and cell cycle progression. We tested the hypothesis that FAK gene silencing would promote anoikis and reverse acquired anoikis resistance in human pancreatic adenocarcinoma cells.
Original languageEnglish
Pages (from-to)555-62
Number of pages8
JournalSurgery
Volume135
Issue number5
DOIs
Publication statusPublished - 2004

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