Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

M S Duxbury; H Ito; M J Zinner; S W Ashley; E E Whang

doi:10.1016/j.surg.2003.10.017

Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

M S Duxbury, H Ito, M J Zinner, S W Ashley, E E Whang

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Inadequate or inappropriate cell-substrate contact triggers a subset of apoptotic cell death, termed anoikis. Resistance to anoikis is a characteristic of malignant cells that is associated with increased tumorigenesis and metastasis. Focal adhesion kinase (FAK) is an important regulator of cell survival and migration and cell cycle progression. We tested the hypothesis that FAK gene silencing would promote anoikis and reverse acquired anoikis resistance in human pancreatic adenocarcinoma cells.

Original language	English
Pages (from-to)	555-62
Number of pages	8
Journal	Surgery
Volume	135
Issue number	5
DOIs	https://doi.org/10.1016/j.surg.2003.10.017
Publication status	Published - 2004

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10.1016/j.surg.2003.10.017

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title = "Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells",

abstract = "Inadequate or inappropriate cell-substrate contact triggers a subset of apoptotic cell death, termed anoikis. Resistance to anoikis is a characteristic of malignant cells that is associated with increased tumorigenesis and metastasis. Focal adhesion kinase (FAK) is an important regulator of cell survival and migration and cell cycle progression. We tested the hypothesis that FAK gene silencing would promote anoikis and reverse acquired anoikis resistance in human pancreatic adenocarcinoma cells.",

author = "Duxbury, {M S} and H Ito and Zinner, {M J} and Ashley, {S W} and Whang, {E E}",

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journal = "Surgery",

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T1 - Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

AU - Duxbury, M S

AU - Ito, H

AU - Zinner, M J

AU - Ashley, S W

AU - Whang, E E

PY - 2004

Y1 - 2004

N2 - Inadequate or inappropriate cell-substrate contact triggers a subset of apoptotic cell death, termed anoikis. Resistance to anoikis is a characteristic of malignant cells that is associated with increased tumorigenesis and metastasis. Focal adhesion kinase (FAK) is an important regulator of cell survival and migration and cell cycle progression. We tested the hypothesis that FAK gene silencing would promote anoikis and reverse acquired anoikis resistance in human pancreatic adenocarcinoma cells.

AB - Inadequate or inappropriate cell-substrate contact triggers a subset of apoptotic cell death, termed anoikis. Resistance to anoikis is a characteristic of malignant cells that is associated with increased tumorigenesis and metastasis. Focal adhesion kinase (FAK) is an important regulator of cell survival and migration and cell cycle progression. We tested the hypothesis that FAK gene silencing would promote anoikis and reverse acquired anoikis resistance in human pancreatic adenocarcinoma cells.

U2 - 10.1016/j.surg.2003.10.017

DO - 10.1016/j.surg.2003.10.017

M3 - Article

C2 - 15118593

SN - 0039-6060

VL - 135

SP - 555

EP - 562

JO - Surgery

JF - Surgery

IS - 5

ER -

Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

Abstract

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