Focal Immune-Mediated White Matter Demyelination Reveals an Age-Associated Increase in Axonal Vulnerability and Decreased Remyelination Efficiency

David W. Hampton*, Neill Innes, Doron Merkler, Chao Zhao, Robin J. M. Franklin, Siddharthan Chandran

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In addition to being an established risk factor for neurodegenerative diseases, age is increasingly recognized as adversely influencing regeneration. Accumulating evidence also suggests that age plays important, although poorly understood, roles with respect to course and prognosis in the degenerative and untreatable later phase of multiple sclerosis. Two experimental models of multiple sclerosis have been particularly influential in modeling the different aspects of neuronal injury and regeneration: global experimental autoimmune encephalomyelitis and focal toxin-mediated injury. Against this background, we report a focal model of immune-mediated demyelinating injury that reliably generates targeted primary demyelination and axonal injury. A detailed pathologic characterization of this model, modified extensively from an earlier study, showed that aged adult animals exhibited increased vulnerability to axonal injury and reduced efficiency of remyelination compared with younger animals. More important, remyelination in aged animals was predominantly Schwann cell mediated, in contrast to the central oligodendrocyte-mediated remyelination that predominated in younger rodents. Together, these findings establish an experimental platform to further study the influence of age on injury and repair in a biologically relevant model of human demyelinating injury. (Am J Pathol 2012, 180: 1897-1905; DOI: 10.1016/j.ajpath.2012.01.018)

Original languageEnglish
Pages (from-to)1897-1905
Number of pages9
JournalAmerican Journal of Pathology
Volume180
Issue number5
DOIs
Publication statusPublished - May 2012

Keywords

  • TOXIN-INDUCED DEMYELINATION
  • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
  • CNS REMYELINATION
  • PERIPHERAL TYPE MYELIN
  • MULTIPLE-SCLEROSIS
  • SCHWANN-CELL REMYELINATION
  • INTRASPINAL INJECTION
  • SPINAL-CORD
  • CENTRAL-NERVOUS-SYSTEM
  • RATS

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