Force-Extension for DNA in a Nanoslit: Mapping between the 3D and 2D Limits

Hendrick W. de Haan; Tyler N. Shendruk

doi:10.1021/acsmacrolett.5b00138

Force-Extension for DNA in a Nanoslit: Mapping between the 3D and 2D Limits

Hendrick W. de Haan, Tyler N. Shendruk

School of Physics and Astronomy

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Abstract / Description of output

The force–extension relation for a semiflexible polymer confined in a nanoslit is investigated. Both the effective correlation length and force–extension relation change as the chain goes from 3D (large slit heights) to 2D (tight confinement). At low forces, correlations along the polymer give an effective dimensionality. The strong force limit can be interpolated with the weak force limit for two regimes: when confinement dominates over extensile force and vice versa. These interpolations give good agreement with simulations for all slit heights and forces. We thus generalize the Marko-Siggia force–extension relation for DNA and other semiflexible biopolymers in nanoconfinement.

Original language	English
Pages (from-to)	632-635
Number of pages	4
Journal	ACS MACRO LETTERS
Volume	4
Issue number	6
Early online date	20 May 2015
DOIs	https://doi.org/10.1021/acsmacrolett.5b00138
Publication status	Published - 16 Jun 2015

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title = "Force-Extension for DNA in a Nanoslit: Mapping between the 3D and 2D Limits",

abstract = "The force–extension relation for a semiflexible polymer confined in a nanoslit is investigated. Both the effective correlation length and force–extension relation change as the chain goes from 3D (large slit heights) to 2D (tight confinement). At low forces, correlations along the polymer give an effective dimensionality. The strong force limit can be interpolated with the weak force limit for two regimes: when confinement dominates over extensile force and vice versa. These interpolations give good agreement with simulations for all slit heights and forces. We thus generalize the Marko-Siggia force–extension relation for DNA and other semiflexible biopolymers in nanoconfinement.",

author = "{de Haan}, {Hendrick W.} and Shendruk, {Tyler N.}",

year = "2015",

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doi = "10.1021/acsmacrolett.5b00138",

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journal = "ACS MACRO LETTERS",

issn = "2161-1653",

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T1 - Force-Extension for DNA in a Nanoslit: Mapping between the 3D and 2D Limits

AU - de Haan, Hendrick W.

AU - Shendruk, Tyler N.

PY - 2015/6/16

Y1 - 2015/6/16

N2 - The force–extension relation for a semiflexible polymer confined in a nanoslit is investigated. Both the effective correlation length and force–extension relation change as the chain goes from 3D (large slit heights) to 2D (tight confinement). At low forces, correlations along the polymer give an effective dimensionality. The strong force limit can be interpolated with the weak force limit for two regimes: when confinement dominates over extensile force and vice versa. These interpolations give good agreement with simulations for all slit heights and forces. We thus generalize the Marko-Siggia force–extension relation for DNA and other semiflexible biopolymers in nanoconfinement.

AB - The force–extension relation for a semiflexible polymer confined in a nanoslit is investigated. Both the effective correlation length and force–extension relation change as the chain goes from 3D (large slit heights) to 2D (tight confinement). At low forces, correlations along the polymer give an effective dimensionality. The strong force limit can be interpolated with the weak force limit for two regimes: when confinement dominates over extensile force and vice versa. These interpolations give good agreement with simulations for all slit heights and forces. We thus generalize the Marko-Siggia force–extension relation for DNA and other semiflexible biopolymers in nanoconfinement.

U2 - 10.1021/acsmacrolett.5b00138

DO - 10.1021/acsmacrolett.5b00138

M3 - Letter

SN - 2161-1653

VL - 4

SP - 632

EP - 635

JO - ACS MACRO LETTERS

JF - ACS MACRO LETTERS

IS - 6

ER -

Force-Extension for DNA in a Nanoslit: Mapping between the 3D and 2D Limits

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