Fortified interpenetrating polymers – bacteria resistant coatings for medical devices

Seshasailam Venkateswaran, Orlando David Henrique Dos Santos, Emma Scholefield, Annamaria Lilienkampf, Peter J. Gwynne, David G. Swann, Kevin Dhaliwal, Maurice P. Gallagher, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.
Original languageEnglish
Pages (from-to)5405-5411
JournalJournal of Materials Chemistry B: Materials for biology and medicine
Volume4
Issue number32
Early online date18 Jul 2016
DOIs
Publication statusE-pub ahead of print - 18 Jul 2016

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