TY - JOUR
T1 - Fortified interpenetrating polymers – bacteria resistant coatings for medical devices
AU - Venkateswaran, Seshasailam
AU - Henrique Dos Santos, Orlando David
AU - Scholefield, Emma
AU - Lilienkampf, Annamaria
AU - Gwynne, Peter J.
AU - Swann, David G.
AU - Dhaliwal, Kevin
AU - Gallagher, Maurice P.
AU - Bradley, Mark
PY - 2016/7/18
Y1 - 2016/7/18
N2 - Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.
AB - Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.
U2 - 10.1039/C6TB01110A
DO - 10.1039/C6TB01110A
M3 - Article
SN - 2050-750X
VL - 4
SP - 5405
EP - 5411
JO - Journal of Materials Chemistry B: Materials for biology and medicine
JF - Journal of Materials Chemistry B: Materials for biology and medicine
IS - 32
ER -