Frailty and Cerebrovascular Disease: Concepts and Clinical Implications for Stroke Medicine

Nicholas R Evans, Oliver M Todd, Jatinder S. Minhas, Patricia Fearon, George W Hartson, Jonathan Mant, Gillian Mead, Jonathan Hewitt, Terence J Quinn, Elizabeth A Warburton

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorbidity, and disability, frailty is a discrete syndrome that is associated with poorer outcomes across a range of medical conditions. However, its role in cerebrovascular disease and stroke has received limited attention. The estimated rise in the prevalence of frailty associated with changing demographics over the coming decades makes it an important issue for stroke practitioners, cerebrovascular research, clinical service provision, and stroke survivors alike. This review will consider the concept and models of frailty, how frailty is common in cerebrovascular disease, the impact of frailty on stroke risk factors, acute treatments, and rehabilitation, and considerations for future applications in both cerebrovascular clinical and research settings.
Original languageEnglish
JournalInternational Journal of Stroke
Early online date4 Aug 2021
Publication statusE-pub ahead of print - 4 Aug 2021


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