Projects per year
NK cells are widely distributed in lymphoid and non-lymphoid tissues however little is known about the recirculation of NK cells between blood and tissues. This is relevant to understanding recirculation in the steady-state and also for determining the roles for NK cells in vaccine-induced immunity and responses to infection. Therefore, the percentage of NK cells and their phenotype across peripheral blood, afferent lymph and lymph nodes in steady-state conditions was investigated in cattle using the pseudo-afferent lymphatic cannulation model. CD2+ CD25lo NK cells were the predominant subset of NK cells within the blood. In contrast, CD2- CD25hi NK cells were the main subset present within the skin-draining afferent lymphatic vessels and lymph nodes, indicating that CD2- NK cells are the principal NK cell subset trafficking to LNs via the afferent lymphatic vessel. Furthermore, a low percentage of NK cells were present in efferent lymph which were predominantly of the CD2- subset indicating that NK cells can egress from lymph nodes and return to circulation in steady-state conditions. These compartmentalisation data indicate that NK cells represent a population of recirculating lymphocytes in steady-state conditions and therefore may be important during immune responses to vaccination or infection.
|Early online date||7 Jan 2017|
|Publication status||Published - May 2017|
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- 2 Finished
Innate immunity and endemic diseases in livestock species
Collie, D., Beard, P., Bishop, S., Bronsvoort, M., Burt, D., Fitzgerald, R., Freeman, T., Gally, D., Gill, A., Glass, E., Hocking, P., Hope, J., Hume, D., Kaiser, P., Mabbott, N., McLachlan, G., Morrison, L., Stevens, J., Stevens, M. & Watson, M.
1/04/12 → 31/03/17
Neonatal vaccinations: role for innate immune cell interactions in BCG vaccination
1/10/11 → 30/09/15
- Royal (Dick) School of Veterinary Studies - Personal Chair of Immunology
- Edinburgh Imaging
Person: Academic: Research Active