Frequency, morbidity and equity – the case for increased research into male reproductive health

Moira K. O’Bryan; Sarah Kimmins; Richard A Anderson; Christopher L.R. Barratt; Hermann Behre; Sarah R. Catford; Christopher De Jonge; Geraldine Delbes; Michael L. Eisenberg; Nicolas Garrido; Brendan J. Houston; Niels Jørgensen; Csilla Krausz; Ariane Lismer; Robert I.  McLachlan; Suks Minhas; Tim Moss; Allan Pacey; Lærke Priskorn; Stefan Schlatt; Jacquetta Trasler; Leonardo Trasande; Frank Tüttelmann; Mónica  Hebe Vazquez-Levin; Joris A.  Veltman; Feng Zhang

doi:10.1038/s41585-023-00820-4

Frequency, morbidity and equity – the case for increased research into male reproductive health

Moira K. O’Bryan, Sarah Kimmins, Richard A Anderson^*, Christopher L.R. Barratt, Hermann Behre, Sarah R. Catford, Christopher De Jonge, Geraldine Delbes, Michael L. Eisenberg, Nicolas Garrido, Brendan J. Houston, Niels Jørgensen, Csilla Krausz, Ariane Lismer, Robert I. McLachlan, Suks Minhas, Tim Moss, Allan Pacey, Lærke Priskorn, Stefan SchlattJacquetta Trasler, Leonardo Trasande, Frank Tüttelmann, Mónica Hebe Vazquez-Levin, Joris A. Veltman, Feng Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Original language	English
Journal	Nature Reviews Urology
Early online date	12 Oct 2023
DOIs	https://doi.org/10.1038/s41585-023-00820-4
Publication status	E-pub ahead of print - 12 Oct 2023

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10.1038/s41585-023-00820-4

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O’Bryan, M. K., Kimmins, S., Anderson, R. A., Barratt, C. L. R., Behre, H., Catford, S. R., De Jonge, C., Delbes, G., Eisenberg, M. L., Garrido, N., Houston, B. J., Jørgensen, N., Krausz, C., Lismer, A., McLachlan, R. I., Minhas, S., Moss, T., Pacey, A., Priskorn, L., ... Zhang, F. (2023). Frequency, morbidity and equity – the case for increased research into male reproductive health. Nature Reviews Urology. Advance online publication. https://doi.org/10.1038/s41585-023-00820-4

@article{b546adb652584269a3710d9167748535,

title = "Frequency, morbidity and equity – the case for increased research into male reproductive health",

author = "O{\textquoteright}Bryan, {Moira K.} and Sarah Kimmins and Anderson, {Richard A} and Barratt, {Christopher L.R.} and Hermann Behre and Catford, {Sarah R.} and {De Jonge}, Christopher and Geraldine Delbes and Eisenberg, {Michael L.} and Nicolas Garrido and Houston, {Brendan J.} and Niels J{\o}rgensen and Csilla Krausz and Ariane Lismer and McLachlan, {Robert I.} and Suks Minhas and Tim Moss and Allan Pacey and L{\ae}rke Priskorn and Stefan Schlatt and Jacquetta Trasler and Leonardo Trasande and Frank T{\"u}ttelmann and {Hebe Vazquez-Levin}, M{\'o}nica and Veltman, {Joris A.} and Feng Zhang",

note = "Funding Information: C.L.R.B. is supported in part by the Bill and Melinda Gates Foundation in the area of contraceptive development, Chief Scientist Office (Scotland), NHS and Genus Healthcare. C.L.R.B. has received fees from Cooper Surgical for lectures on scientific research methods outside the submitted work and Ferring for a lecture on the future of male reproductive health. M.L.E. is an adviser to Ro, Doveras, VSeat, and Next. R.A.A. reports grants and personal fees from Roche Diagnostics, personal fees from Ferring Pharmaceuticals, IBSA, Merck Serono, outside the submitted work. S.K. is an inventor on a Provisional patent 14647-P68337CA00 10 June 2022: Methods for identifying epigenetic modifications in sperm, diagnosing infertility, and identifying treatment strategies. A.P. has undertaken paid consultancy for Cryos International, Cytoswim Ltd, Exceed Health, Meals Group, and Merck Serono in the last 2 years, but all monies have been paid to the University of Sheffield (former employer). M.K.O. is supported in part by the Bill and Melinda Gates Foundation in the area of contraceptive development. All other authors declare no competing interests. Funding Information: Effective ways of optimizing men{\textquoteright}s fertility before conception are largely unexplored, and the reproductive outcomes of any resulting interventions are unknown. Research funding agencies, health institutions and governments must respond to the need for knowledge in this area to ensure that interventions are evidence based, acceptable, effective and affordable. An example of the work required is provided by the Australian Male Infertility Exposure Study , funded by the Australian Medical Research Future Fund. The aim of the study is to understand how health, lifestyle and environmental factors can influence male infertility and treatment outcomes for male infertility. Funding Information: Thanks goes to R. Agnew, E. Heighton and A. Mergo from The University of Dundee for their assistance with data collection for Fig. . Thanks also goes to A. O{\textquoteright}Connor from the University of Melbourne for assistance with referencing. This research was supported in part by funding by the National Health and Medical Research Council of Australia to M.K.O., R.I.M. and J.A.V. (APP1120356); S.K. is a Canada Research Chair in Epigenomics, Reproduction and Development and funding for this study is provided by the Canada Research Chairs program, and the Canadian Institutes of Health Research grants (DOHaD Team grant 358654 and Operating grant 350129). The authors thank ESHRE for financial and logistical support of the MRHI. Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",

year = "2023",

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doi = "10.1038/s41585-023-00820-4",

language = "English",

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O’Bryan, MK, Kimmins, S, Anderson, RA, Barratt, CLR, Behre, H, Catford, SR, De Jonge, C, Delbes, G, Eisenberg, ML, Garrido, N, Houston, BJ, Jørgensen, N, Krausz, C, Lismer, A, McLachlan, RI, Minhas, S, Moss, T, Pacey, A, Priskorn, L, Schlatt, S, Trasler, J, Trasande, L, Tüttelmann, F, Hebe Vazquez-Levin, M, Veltman, JA & Zhang, F 2023, 'Frequency, morbidity and equity – the case for increased research into male reproductive health', Nature Reviews Urology. https://doi.org/10.1038/s41585-023-00820-4

TY - JOUR

T1 - Frequency, morbidity and equity – the case for increased research into male reproductive health

AU - O’Bryan, Moira K.

AU - Kimmins, Sarah

AU - Anderson, Richard A

AU - Barratt, Christopher L.R.

AU - Behre, Hermann

AU - Catford, Sarah R.

AU - De Jonge, Christopher

AU - Delbes, Geraldine

AU - Eisenberg, Michael L.

AU - Garrido, Nicolas

AU - Houston, Brendan J.

AU - Jørgensen, Niels

AU - Krausz, Csilla

AU - Lismer, Ariane

AU - McLachlan, Robert I.

AU - Minhas, Suks

AU - Moss, Tim

AU - Pacey, Allan

AU - Priskorn, Lærke

AU - Schlatt, Stefan

AU - Trasler, Jacquetta

AU - Trasande, Leonardo

AU - Tüttelmann, Frank

AU - Hebe Vazquez-Levin, Mónica

AU - Veltman, Joris A.

AU - Zhang, Feng

N1 - Funding Information: C.L.R.B. is supported in part by the Bill and Melinda Gates Foundation in the area of contraceptive development, Chief Scientist Office (Scotland), NHS and Genus Healthcare. C.L.R.B. has received fees from Cooper Surgical for lectures on scientific research methods outside the submitted work and Ferring for a lecture on the future of male reproductive health. M.L.E. is an adviser to Ro, Doveras, VSeat, and Next. R.A.A. reports grants and personal fees from Roche Diagnostics, personal fees from Ferring Pharmaceuticals, IBSA, Merck Serono, outside the submitted work. S.K. is an inventor on a Provisional patent 14647-P68337CA00 10 June 2022: Methods for identifying epigenetic modifications in sperm, diagnosing infertility, and identifying treatment strategies. A.P. has undertaken paid consultancy for Cryos International, Cytoswim Ltd, Exceed Health, Meals Group, and Merck Serono in the last 2 years, but all monies have been paid to the University of Sheffield (former employer). M.K.O. is supported in part by the Bill and Melinda Gates Foundation in the area of contraceptive development. All other authors declare no competing interests. Funding Information: Effective ways of optimizing men’s fertility before conception are largely unexplored, and the reproductive outcomes of any resulting interventions are unknown. Research funding agencies, health institutions and governments must respond to the need for knowledge in this area to ensure that interventions are evidence based, acceptable, effective and affordable. An example of the work required is provided by the Australian Male Infertility Exposure Study , funded by the Australian Medical Research Future Fund. The aim of the study is to understand how health, lifestyle and environmental factors can influence male infertility and treatment outcomes for male infertility. Funding Information: Thanks goes to R. Agnew, E. Heighton and A. Mergo from The University of Dundee for their assistance with data collection for Fig. . Thanks also goes to A. O’Connor from the University of Melbourne for assistance with referencing. This research was supported in part by funding by the National Health and Medical Research Council of Australia to M.K.O., R.I.M. and J.A.V. (APP1120356); S.K. is a Canada Research Chair in Epigenomics, Reproduction and Development and funding for this study is provided by the Canada Research Chairs program, and the Canadian Institutes of Health Research grants (DOHaD Team grant 358654 and Operating grant 350129). The authors thank ESHRE for financial and logistical support of the MRHI. Publisher Copyright: © 2023, Springer Nature Limited.

PY - 2023/10/12

Y1 - 2023/10/12

U2 - 10.1038/s41585-023-00820-4

DO - 10.1038/s41585-023-00820-4

M3 - Review article

SN - 1759-4812

JO - Nature Reviews Urology

JF - Nature Reviews Urology

ER -