Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

R A Lothe; N Hastie; K Heimdal; S D Fosså; A E Stenwig; A L Børresen

Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

R A Lothe, N Hastie, K Heimdal, S D Fosså, A E Stenwig, A L Børresen

Research output: Contribution to journal › Article › peer-review

Abstract

Deletions within the short arm of the human chromosome 11 have been found to be involved in the genesis of several tumours, including different urogenital neoplasms. We have studied 31 male germ cell tumours (19 seminomas and 12 nonseminomas), and observed loss of heterozygosity at 11p loci in 40% (12/30) of these tumours [35% (9/26) at 11p13 and 31% (8/26) at 11p15]. Our data suggest that inactivation of one or more tumour suppressor genes on 11p are involved in the genesis of testicular cancer. In addition, identification of the parental origin of the allelic losses revealed a paternal loss in six patients and a maternal loss in one case.

Original language	English
Pages (from-to)	96-101
Number of pages	6
Journal	Genes, Chromosomes and Cancer
Volume	7
Issue number	2
Publication status	Published - Jun 1993

Keywords

Carcinoma in Situ
Chromosomes, Human, Pair 11
Dysgerminoma
Gene Deletion
Heterozygote
Humans
Male
Mesonephroma
Teratoma
Testicular Neoplasms

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title = "Frequent loss of 11p13 and 11p15 loci in male germ cell tumours",

abstract = "Deletions within the short arm of the human chromosome 11 have been found to be involved in the genesis of several tumours, including different urogenital neoplasms. We have studied 31 male germ cell tumours (19 seminomas and 12 nonseminomas), and observed loss of heterozygosity at 11p loci in 40% (12/30) of these tumours [35% (9/26) at 11p13 and 31% (8/26) at 11p15]. Our data suggest that inactivation of one or more tumour suppressor genes on 11p are involved in the genesis of testicular cancer. In addition, identification of the parental origin of the allelic losses revealed a paternal loss in six patients and a maternal loss in one case.",

keywords = "Carcinoma in Situ, Chromosomes, Human, Pair 11, Dysgerminoma, Gene Deletion, Heterozygote, Humans, Male, Mesonephroma, Teratoma, Testicular Neoplasms",

author = "Lothe, {R A} and N Hastie and K Heimdal and Foss{\aa}, {S D} and Stenwig, {A E} and B{\o}rresen, {A L}",

year = "1993",

month = jun,

language = "English",

volume = "7",

pages = "96--101",

journal = "Genes, Chromosomes and Cancer",

issn = "1045-2257",

publisher = "Wiley-Liss Inc.",

number = "2",

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TY - JOUR

T1 - Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

AU - Lothe, R A

AU - Hastie, N

AU - Heimdal, K

AU - Fosså, S D

AU - Stenwig, A E

AU - Børresen, A L

PY - 1993/6

Y1 - 1993/6

N2 - Deletions within the short arm of the human chromosome 11 have been found to be involved in the genesis of several tumours, including different urogenital neoplasms. We have studied 31 male germ cell tumours (19 seminomas and 12 nonseminomas), and observed loss of heterozygosity at 11p loci in 40% (12/30) of these tumours [35% (9/26) at 11p13 and 31% (8/26) at 11p15]. Our data suggest that inactivation of one or more tumour suppressor genes on 11p are involved in the genesis of testicular cancer. In addition, identification of the parental origin of the allelic losses revealed a paternal loss in six patients and a maternal loss in one case.

AB - Deletions within the short arm of the human chromosome 11 have been found to be involved in the genesis of several tumours, including different urogenital neoplasms. We have studied 31 male germ cell tumours (19 seminomas and 12 nonseminomas), and observed loss of heterozygosity at 11p loci in 40% (12/30) of these tumours [35% (9/26) at 11p13 and 31% (8/26) at 11p15]. Our data suggest that inactivation of one or more tumour suppressor genes on 11p are involved in the genesis of testicular cancer. In addition, identification of the parental origin of the allelic losses revealed a paternal loss in six patients and a maternal loss in one case.

KW - Carcinoma in Situ

KW - Chromosomes, Human, Pair 11

KW - Dysgerminoma

KW - Gene Deletion

KW - Heterozygote

KW - Humans

KW - Male

KW - Mesonephroma

KW - Teratoma

KW - Testicular Neoplasms

M3 - Article

C2 - 7687459

VL - 7

SP - 96

EP - 101

JO - Genes, Chromosomes and Cancer

JF - Genes, Chromosomes and Cancer

SN - 1045-2257

IS - 2

ER -

Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

Abstract

Keywords

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