Fruitful Decades for Canthin-6-ones from 1952 to 2015: Biosynthesis, Chemistry, and Biological Activities

Jiangkun Dai; Na Li; Junru Wang; Uwe Schneider

doi:10.3390/molecules21040493

Fruitful Decades for Canthin-6-ones from 1952 to 2015: Biosynthesis, Chemistry, and Biological Activities

Jiangkun Dai, Na Li, Junru Wang, Uwe Schneider

School of Chemistry

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

In this review, more than 60 natural canthin-6-one alkaloids and their structures are considered. The biosynthesis, efficient and classic synthetic approaches, and biological activities of canthin-6-one alkaloids, from 1952 to 2015, are discussed. From an analysis of their structural properties and an investigation of the literature, possible future trends for canthin-6-one alkaloids are proposed. The information reported will be helpful in future research on canthin-6-one alkaloids.

Original language	English
Article number	493
Number of pages	13
Journal	Molecules
Volume	21
Issue number	4
DOIs	https://doi.org/10.3390/molecules21040493
Publication status	Published - 15 Apr 2016

Keywords / Materials (for Non-textual outputs)

canthin-6-one
biosynthesis
chemistry
biological activities
BETA-CARBOLINE ALKALOIDS
CHILOPERONE VAR. ANGUSTIFOLIUM
CATALYZED AMIDATION REACTION
NITRIC-OXIDE PRODUCTION
EURYCOMA-LONGIFOLIA
ZANTHOXYLUM-CHILOPERONE
AILANTHUS-ALTISSIMA
5,5-DISUBSTITUTED 4,5-DIHYDRO-6H-CANTHIN-6-ONES
ANTIPROLIFERATIVE ACTIVITY
ANTIMALARIAL CONSTITUENTS

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10.3390/molecules21040493Licence: Creative Commons: Attribution (CC-BY)

20170207 Schneider molecules-21-00493 (2)Final published version, 2.67 MBLicence: Creative Commons: Attribution (CC-BY)

http://www.mdpi.com/1420-3049/21/4/493

Cite this

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title = "Fruitful Decades for Canthin-6-ones from 1952 to 2015: Biosynthesis, Chemistry, and Biological Activities",

abstract = "In this review, more than 60 natural canthin-6-one alkaloids and their structures are considered. The biosynthesis, efficient and classic synthetic approaches, and biological activities of canthin-6-one alkaloids, from 1952 to 2015, are discussed. From an analysis of their structural properties and an investigation of the literature, possible future trends for canthin-6-one alkaloids are proposed. The information reported will be helpful in future research on canthin-6-one alkaloids.",

keywords = "canthin-6-one, biosynthesis, chemistry, biological activities, BETA-CARBOLINE ALKALOIDS, CHILOPERONE VAR. ANGUSTIFOLIUM, CATALYZED AMIDATION REACTION, NITRIC-OXIDE PRODUCTION, EURYCOMA-LONGIFOLIA, ZANTHOXYLUM-CHILOPERONE, AILANTHUS-ALTISSIMA, 5,5-DISUBSTITUTED 4,5-DIHYDRO-6H-CANTHIN-6-ONES, ANTIPROLIFERATIVE ACTIVITY, ANTIMALARIAL CONSTITUENTS",

author = "Jiangkun Dai and Na Li and Junru Wang and Uwe Schneider",

year = "2016",

month = apr,

day = "15",

doi = "10.3390/molecules21040493",

language = "English",

volume = "21",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

TY - JOUR

T1 - Fruitful Decades for Canthin-6-ones from 1952 to 2015

T2 - Biosynthesis, Chemistry, and Biological Activities

AU - Dai, Jiangkun

AU - Li, Na

AU - Wang, Junru

AU - Schneider, Uwe

PY - 2016/4/15

Y1 - 2016/4/15

N2 - In this review, more than 60 natural canthin-6-one alkaloids and their structures are considered. The biosynthesis, efficient and classic synthetic approaches, and biological activities of canthin-6-one alkaloids, from 1952 to 2015, are discussed. From an analysis of their structural properties and an investigation of the literature, possible future trends for canthin-6-one alkaloids are proposed. The information reported will be helpful in future research on canthin-6-one alkaloids.

AB - In this review, more than 60 natural canthin-6-one alkaloids and their structures are considered. The biosynthesis, efficient and classic synthetic approaches, and biological activities of canthin-6-one alkaloids, from 1952 to 2015, are discussed. From an analysis of their structural properties and an investigation of the literature, possible future trends for canthin-6-one alkaloids are proposed. The information reported will be helpful in future research on canthin-6-one alkaloids.

KW - canthin-6-one

KW - biosynthesis

KW - chemistry

KW - biological activities

KW - BETA-CARBOLINE ALKALOIDS

KW - CHILOPERONE VAR. ANGUSTIFOLIUM

KW - CATALYZED AMIDATION REACTION

KW - NITRIC-OXIDE PRODUCTION

KW - EURYCOMA-LONGIFOLIA

KW - ZANTHOXYLUM-CHILOPERONE

KW - AILANTHUS-ALTISSIMA

KW - 5,5-DISUBSTITUTED 4,5-DIHYDRO-6H-CANTHIN-6-ONES

KW - ANTIPROLIFERATIVE ACTIVITY

KW - ANTIMALARIAL CONSTITUENTS

U2 - 10.3390/molecules21040493

DO - 10.3390/molecules21040493

M3 - Literature review

SN - 1420-3049

VL - 21

JO - Molecules

JF - Molecules

IS - 4

M1 - 493

ER -

Fruitful Decades for Canthin-6-ones from 1952 to 2015: Biosynthesis, Chemistry, and Biological Activities

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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