Full-length sequence analysis of SIVmus in wild populations of mustached monkeys (Cercopithecus cephus) from Cameroon provides evidence for two co-circulating SIVmus lineages

Avelin F. Aghokeng, Elizabeth Bailes, Severin Loul, Valerie Courgnaud, Eitel Mpoudi-Ngolle, Paul M. Sharp, Eric Delaporte, Martine Peeters

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Mustached monkeys (Cercopithecus cephus), which form a significant component of primate bushmeat in west central Africa, are infected with simian immunodeficiency virus (SIVmus). We identified and genetically characterized five new SlVmus strains infecting wild living mustached monkeys from Cameroon. Phylogenetic analysis of partial pol sequences revealed that SlVmus strains form two distinct groups within the clade comprised of lentiviruses isolated from Cercopithecus nictitans (SIVgsn), Cercopithecus mona (SIVmon) and C cephus (SlVmus). Characterisation of three full-length SIVmus genomes confirmed the presence of two distinct lineages infecting mustached monkeys. These two variants of SIVmus, here designated SIVmus-1 and SIVmus-2, were isolated from animals sharing habitats within the same geographic region. Phylogenetic analyses showed that the diversification of SlVmus, SIVgsn and SIVmon involved inter-lineage recombination, and suggested that one of the SIVmus lineages likely resulted from cross-species transmission and recombination involving SIVmus and an as yet uncharacterized SIV. These results indicate that cross-species transmission and recombination play a major role in the evolution of primate lentiviruses among sympatric primate species. (c) 2006 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)407-418
Number of pages12
JournalVirology
Volume360
Issue number2
DOIs
Publication statusPublished - 10 Apr 2007

Fingerprint

Dive into the research topics of 'Full-length sequence analysis of SIVmus in wild populations of mustached monkeys (Cercopithecus cephus) from Cameroon provides evidence for two co-circulating SIVmus lineages'. Together they form a unique fingerprint.

Cite this