Fulvestrant, an estrogen receptor downregulator, reduces cell turnover index more effectively than tamoxifen

Nigel J Bundred, Elizabeth Anderson, Robert I Nicholson, Mitchell Dowsett, Michael Dixon, John F Robertson

Research output: Contribution to journalArticlepeer-review

Abstract

This study was performed to determine whether drug action on breast tumours could also be analysed using a cell turnover index (CTI), a composite measurement of both proliferation and apoptosis.
Original languageEnglish
Pages (from-to)2317-9
Number of pages3
JournalAnticancer research
Volume22
Issue number4
Publication statusPublished - 2002

Keywords

  • Antineoplastic Agents
  • Apoptosis
  • Breast Neoplasms
  • Cell Division
  • Estradiol
  • Estrogen Receptor Modulators
  • Female
  • Humans
  • Ki-67 Antigen
  • Kinetics
  • Placebos
  • Tamoxifen
  • Tumor Cells, Cultured

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